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Research Article

Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes

  • Emilio Lecona,

    Affiliations: Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America, Spanish National Cancer Research Centre (CNIO), Molecular Oncology Programme, Madrid, Spain

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  • Luis Alejandro Rojas,

    Affiliation: Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America

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  • Roberto Bonasio,

    Affiliation: Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America

    Current address: Department of Cell and Developmental Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Andrew Johnston,

    Affiliation: Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America

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  • Oscar Fernández-Capetillo,

    Affiliation: Spanish National Cancer Research Centre (CNIO), Molecular Oncology Programme, Madrid, Spain

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  • Danny Reinberg mail

    Danny.Reinberg@nyumc.org

    Affiliation: Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America

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  • Published: December 17, 2013
  • DOI: 10.1371/journal.pbio.1001737

About the Authors

Emilio Lecona, Luis Alejandro Rojas, Roberto Bonasio, Andrew Johnston, Danny Reinberg
Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York, United States of America
Emilio Lecona, Oscar Fernández-Capetillo
Spanish National Cancer Research Centre (CNIO), Molecular Oncology Programme, Madrid, Spain

Corresponding Author

Email: Danny.Reinberg@nyumc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: EL DR. Performed the experiments: EL LR RB AJ. Analyzed the data: EL RB DR. Contributed reagents/materials/analysis tools: EL AR OF. Wrote the paper: EL DR.