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Research Article

Heat Shock Transcription Factor σ32 Co-opts the Signal Recognition Particle to Regulate Protein Homeostasis in E. coli

  • Bentley Lim,

    Affiliation: Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America

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  • Ryoji Miyazaki equal contributor,

    equal contributor Contributed equally to this work with: Ryoji Miyazaki, Saskia Neher

    Affiliation: Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Saskia Neher equal contributor,

    equal contributor Contributed equally to this work with: Ryoji Miyazaki, Saskia Neher

    Affiliation: Department of Biochemistry and Biophysics and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California United States of America

    Current address: Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

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  • Deborah A. Siegele,

    Affiliation: Department of Biology, Texas A&M University, College Station, Texas, United States of America

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  • Koreaki Ito,

    Affiliation: Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan

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  • Peter Walter,

    Affiliation: Department of Biochemistry and Biophysics and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California United States of America

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  • Yoshinori Akiyama mail,

    yakiyama@virus.kyoto-u.ac.jp (Y.A.); yura.takashi.62x@st.kyoto-u.ac.jp (T.Y.); cgrossucsf@gmail.com (C.A.G.)

    Affiliation: Institute for Virus Research, Kyoto University, Kyoto, Japan

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  • Takashi Yura mail,

    yakiyama@virus.kyoto-u.ac.jp (Y.A.); yura.takashi.62x@st.kyoto-u.ac.jp (T.Y.); cgrossucsf@gmail.com (C.A.G.)

    Affiliation: Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan

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  • Carol A. Gross mail

    yakiyama@virus.kyoto-u.ac.jp (Y.A.); yura.takashi.62x@st.kyoto-u.ac.jp (T.Y.); cgrossucsf@gmail.com (C.A.G.)

    Affiliations: Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America, Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California, United States

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  • Published: December 17, 2013
  • DOI: 10.1371/journal.pbio.1001735

About the Authors

Bentley Lim, Carol A. Gross
Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California, United States of America
Ryoji Miyazaki, Yoshinori Akiyama
Institute for Virus Research, Kyoto University, Kyoto, Japan
Saskia Neher, Peter Walter
Department of Biochemistry and Biophysics and Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California United States of America
Deborah A. Siegele
Department of Biology, Texas A&M University, College Station, Texas, United States of America
Koreaki Ito, Takashi Yura
Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, Japan
Carol A. Gross
Department of Cell and Tissue Biology, University of California at San Francisco, San Francisco, California, United States

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BL SN YA DAS TY CAG. Performed the experiments: BL RM TY DAS. Analyzed the data: BL RM SN YA TY. Wrote the paper: BL KI YA PW TY CAG.