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Research Article

Fitness Trade-offs Restrict the Evolution of Resistance to Amphotericin B

  • Benjamin Matteson Vincent,

    Affiliations: Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Alex Kelvin Lancaster,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

    Current address: Department of Pathology, Beth Israel Deaconess Medical Center and Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ruth Scherz-Shouval,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Luke Whitesell,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Susan Lindquist mail

    Lindquist_admin@wi.mit.edu

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Published: October 29, 2013
  • DOI: 10.1371/journal.pbio.1001692
  • Featured in PLOS Collections

About the Authors

Benjamin Matteson Vincent
Microbiology Graduate Program, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Benjamin Matteson Vincent, Alex Kelvin Lancaster, Ruth Scherz-Shouval, Luke Whitesell, Susan Lindquist
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Susan Lindquist
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: Lindquist_admin@wi.mit.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BMV AKL SL. Performed the experiments: BMV AKL RSS LW. Analyzed the data: BMV AKL SLL. Contributed reagents/materials/analysis tools: BMV AKL. Wrote the paper: BMV SL.