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Research Article

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

  • Hiruy S. Meharena,

    Affiliation: Biomedical Sciences, University of California, San Diego, La Jolla, California, United States of America

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  • Philip Chang,

    Affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

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  • Malik M. Keshwani,

    Affiliation: Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America

    X
  • Krishnadev Oruganty,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

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  • Aishwarya K. Nene,

    Affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America

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  • Natarajan Kannan,

    Affiliations: Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America, Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America

    X
  • Susan S. Taylor mail,

    staylor@ucsd.edu (SST); akornev@ucsd.edu (APK)

    Affiliations: Biomedical Sciences, University of California, San Diego, La Jolla, California, United States of America, Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, United States of America

    X
  • Alexandr P. Kornev mail

    staylor@ucsd.edu (SST); akornev@ucsd.edu (APK)

    Affiliations: Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, United States of America

    X
  • Published: October 15, 2013
  • DOI: 10.1371/journal.pbio.1001680

About the Authors

Hiruy S. Meharena, Susan S. Taylor
Biomedical Sciences, University of California, San Diego, La Jolla, California, United States of America
Philip Chang, Aishwarya K. Nene, Susan S. Taylor
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California, United States of America
Malik M. Keshwani, Susan S. Taylor, Alexandr P. Kornev
Department of Pharmacology, University of California, San Diego, La Jolla, California, United States of America
Krishnadev Oruganty, Natarajan Kannan
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia, United States of America
Krishnadev Oruganty, Natarajan Kannan
Institute of Bioinformatics, University of Georgia, Athens, Georgia, United States of America
Susan S. Taylor, Alexandr P. Kornev
Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HSM. Performed the experiments: HSM PC MMK KO AKN. Analyzed the data: HSM. Contributed reagents/materials/analysis tools: SST NK APK. Wrote the paper: HSM.