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Research Article

TGF-β Signalling Is Required for CD4+ T Cell Homeostasis But Dispensable for Regulatory T Cell Function

  • Anna Śledzińska,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Saskia Hemmers,

    Affiliation: Institute for Genetics, University of Cologne, Cologne, Germany

    Current address: Howard Hughes Medical Institute and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America.

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  • Florian Mair,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Oliver Gorka,

    Affiliation: Clinical Chemistry, Klinikum rechts der Isar, Technische Universität München, Germany

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  • Jürgen Ruland,

    Affiliation: Clinical Chemistry, Klinikum rechts der Isar, Technische Universität München, Germany

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  • Lynsey Fairbairn,

    Affiliation: Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Germany

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  • Anja Nissler,

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Werner Müller,

    Affiliation: Department of Experimental Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany

    Current address: Bill Ford Chair of Cellular Immunology, Faculty of Life Science, University of Manchester, Manchester, United Kingdom.

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  • Ari Waisman,

    Affiliations: Institute for Genetics, University of Cologne, Cologne, Germany, Institute for Molecular Medicine, University Medical Center of the Johannes-Gutenberg University of Mainz, Mainz, Germany

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  • Burkhard Becher equal contributor mail,

    equal contributor Contributed equally to this work with: Burkhard Becher, Thorsten Buch

    Thorsten.Buch@mikrobio.med.tum.de (TB); becher@immunology.uzh.ch (BB)

    Affiliation: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland

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  • Thorsten Buch equal contributor mail

    equal contributor Contributed equally to this work with: Burkhard Becher, Thorsten Buch

    Thorsten.Buch@mikrobio.med.tum.de (TB); becher@immunology.uzh.ch (BB)

    Affiliations: Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland, Institute for Genetics, University of Cologne, Cologne, Germany, Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Germany

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  • Published: October 08, 2013
  • DOI: 10.1371/journal.pbio.1001674

About the Authors

Anna Śledzińska, Florian Mair, Anja Nissler, Burkhard Becher, Thorsten Buch
Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
Saskia Hemmers, Ari Waisman, Thorsten Buch
Institute for Genetics, University of Cologne, Cologne, Germany
Oliver Gorka, Jürgen Ruland
Clinical Chemistry, Klinikum rechts der Isar, Technische Universität München, Germany
Lynsey Fairbairn, Thorsten Buch
Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Germany
Werner Müller
Department of Experimental Immunology, Helmholtz Center for Infection Research, Braunschweig, Germany
Ari Waisman
Institute for Molecular Medicine, University Medical Center of the Johannes-Gutenberg University of Mainz, Mainz, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AS SH TB BB. Performed the experiments: AS SH FM AN OG LF. Analyzed the data: AS SH FM AN OG LF. Contributed reagents/materials/analysis tools: OG JR. Wrote the paper: AS TB BB. Supervised the work: TB BB AW WM JR.