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Research Article

Design Principles of the Yeast G1/S Switch

  • Xiaojing Yang equal contributor,

    equal contributor Contributed equally to this work with: Xiaojing Yang, Kai-Yeung Lau, Volkan Sevim

    Affiliations: Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China, Department of Bioengineering and Therapeutic Sciences, and Center for Systems and Synthetic Biology, University of California, San Francisco, California, United States of America

    X
  • Kai-Yeung Lau equal contributor,

    equal contributor Contributed equally to this work with: Xiaojing Yang, Kai-Yeung Lau, Volkan Sevim

    Affiliation: Department of Bioengineering and Therapeutic Sciences, and Center for Systems and Synthetic Biology, University of California, San Francisco, California, United States of America

    Current address: Discovery Toxicology, Comparative Biology and Safety Sciences, Amgen, 1201 Amgen Court West, Seattle, Washington, United States of America

    X
  • Volkan Sevim equal contributor,

    equal contributor Contributed equally to this work with: Xiaojing Yang, Kai-Yeung Lau, Volkan Sevim

    Affiliation: Department of Bioengineering and Therapeutic Sciences, and Center for Systems and Synthetic Biology, University of California, San Francisco, California, United States of America

    X
  • Chao Tang mail

    tangc@pku.edu.cn

    Affiliation: Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China

    X
  • Published: October 01, 2013
  • DOI: 10.1371/journal.pbio.1001673

About the Authors

Xiaojing Yang, Chao Tang
Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China
Xiaojing Yang, Kai-Yeung Lau, Volkan Sevim
Department of Bioengineering and Therapeutic Sciences, and Center for Systems and Synthetic Biology, University of California, San Francisco, California, United States of America

Corresponding Author

Email: tangc@pku.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: XY KYL VS CT. Performed the experiments: XY KYL. Analyzed the data: XJ KYL. Contributed reagents/materials/analysis tools: XY KYL VS. Wrote the paper: XY KYL VS CT. Built the stochastic model: KYL. Built the in silico evolution model: VS.