Advertisement
Research Article

NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis

  • Brigitte Ritter mail,

    britter@bu.edu (BR); peter.mcpherson@mcgill.ca (PSM)

    Affiliations: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Sebastian Murphy,

    Affiliation: Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec, Canada

    X
  • Hatem Dokainish,

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    X
  • Martine Girard,

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    X
  • Manasa V. Gudheti,

    Affiliations: Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah, United States of America, Vutara, Inc., Salt Lake City, Utah, United States of America

    X
  • Guennadi Kozlov,

    Affiliation: Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec, Canada

    X
  • Marilene Halin,

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    X
  • Jacynthe Philie,

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    X
  • Erik M. Jorgensen,

    Affiliation: Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah, United States of America

    X
  • Kalle Gehring,

    Affiliation: Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec, Canada

    X
  • Peter S. McPherson mail

    britter@bu.edu (BR); peter.mcpherson@mcgill.ca (PSM)

    Affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

    X
  • Published: October 01, 2013
  • DOI: 10.1371/journal.pbio.1001670

About the Authors

Brigitte Ritter, Hatem Dokainish, Martine Girard, Marilene Halin, Jacynthe Philie, Peter S. McPherson
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Brigitte Ritter
Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America
Sebastian Murphy, Guennadi Kozlov, Kalle Gehring
Department of Biochemistry, Groupe de Recherche Axé sur la Structure des Protéines, McGill University, Montreal, Quebec, Canada
Manasa V. Gudheti, Erik M. Jorgensen
Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City, Utah, United States of America
Manasa V. Gudheti
Vutara, Inc., Salt Lake City, Utah, United States of America

Corresponding Authors

Competing Interests

MVG is an employee of Vutara Inc. The authors used Vutara microscopes and software to collect images and analyze the data.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BR SM HD MG MVG GK EMJ KG PSM. Performed the experiments: BR SM HD MG MVG GK MH JP. Analyzed the data: BR SM HD MG MVG GK EMJ KG PSM. Contributed reagents/materials/analysis tools: EMJ. Wrote the paper: BR PSM.