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Research Article

Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism

  • Ross A. Breckenridge mail,

    rbrecke@nimr.mrc.ac.uk

    Affiliations: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom, Division of Medicine, University College London, London, United Kingdom

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  • Izabela Piotrowska,

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Keat-Eng Ng,

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Timothy J. Ragan,

    Affiliation: Division of Molecular Structure, MRC–National Institute for Medical Research, London, United Kingdom

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  • James A. West,

    Affiliation: Department of Biochemistry, Cambridge University, Cambridge, United Kingdom

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  • Surendra Kotecha,

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Norma Towers,

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Michael Bennett,

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Petra C. Kienesberger,

    Affiliation: Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Ryszard T. Smolenski,

    Affiliation: Department of Biochemistry, Medical University of Gdansk, Poland

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  • Hillary K. Siddall,

    Affiliation: Hatter Institute, Institute of Cardiovascular Sciences, University College London, London, United Kingdom

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  • John L. Offer,

    Affiliation: Physical Biochemistry, MRC–National Institute for Medical Research, London, United Kingdom

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  • Mihaela M. Mocanu,

    Affiliation: Hatter Institute, Institute of Cardiovascular Sciences, University College London, London, United Kingdom

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  • Derek M. Yelon,

    Affiliation: Hatter Institute, Institute of Cardiovascular Sciences, University College London, London, United Kingdom

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  • Jason R. B. Dyck,

    Affiliation: Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada

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  • Jules L. Griffin,

    Affiliation: Department of Biochemistry, Cambridge University, Cambridge, United Kingdom

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  • Andrey Y. Abramov,

    Affiliation: Institute of Neurology, University College London, London, United Kingdom

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  • Alex P. Gould,

    Affiliation: Division of Physiology and Metabolism, MRC–National Institute for Medical Research, London, United Kingdom

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  • Timothy J. Mohun

    Affiliation: Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom

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  • Published: September 24, 2013
  • DOI: 10.1371/journal.pbio.1001666

About the Authors

Ross A. Breckenridge, Izabela Piotrowska, Keat-Eng Ng, Surendra Kotecha, Norma Towers, Michael Bennett, Timothy J. Mohun
Developmental Biology, MRC–National Institute for Medical Research, London, United Kingdom
Ross A. Breckenridge
Division of Medicine, University College London, London, United Kingdom
Timothy J. Ragan
Division of Molecular Structure, MRC–National Institute for Medical Research, London, United Kingdom
James A. West, Jules L. Griffin
Department of Biochemistry, Cambridge University, Cambridge, United Kingdom
Petra C. Kienesberger, Jason R. B. Dyck
Cardiovascular Research Centre, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
Ryszard T. Smolenski
Department of Biochemistry, Medical University of Gdansk, Poland
Hillary K. Siddall, Mihaela M. Mocanu, Derek M. Yelon
Hatter Institute, Institute of Cardiovascular Sciences, University College London, London, United Kingdom
John L. Offer
Physical Biochemistry, MRC–National Institute for Medical Research, London, United Kingdom
Andrey Y. Abramov
Institute of Neurology, University College London, London, United Kingdom
Alex P. Gould
Division of Physiology and Metabolism, MRC–National Institute for Medical Research, London, United Kingdom

Corresponding Author

Email: rbrecke@nimr.mrc.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RB TM. Performed the experiments: RB IP KE TR JW SK NT MB PK RS HS. Analyzed the data: RB JO MM DY JD JG AA AG TM. Wrote the paper: RB AG TM.