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Research Article

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

  • Tobias Eckle equal contributor,

    equal contributor Contributed equally to this work with: Tobias Eckle, Kelley Brodsky

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Kelley Brodsky equal contributor,

    equal contributor Contributed equally to this work with: Tobias Eckle, Kelley Brodsky

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Megan Bonney,

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Thomas Packard,

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Jun Han,

    Affiliation: University of Victoria–Genome BC Proteomics Centre, Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

    X
  • Christoph H. Borchers,

    Affiliation: University of Victoria–Genome BC Proteomics Centre, Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada

    X
  • Thomas J. Mariani,

    Affiliation: University of Rochester, Center for Pediatric Biomedical Research, Rochester, New York, United States of America

    X
  • Douglas J. Kominsky,

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Michel Mittelbronn,

    Affiliation: Institute of Neurology (Edinger Institute), University of Frankfurt, Frankfurt, Germany

    X
  • Holger K. Eltzschig mail

    holger.eltzschig@ucdenver.edu

    Affiliation: Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America

    X
  • Published: September 24, 2013
  • DOI: 10.1371/journal.pbio.1001665

About the Authors

Tobias Eckle, Kelley Brodsky, Megan Bonney, Thomas Packard, Douglas J. Kominsky, Holger K. Eltzschig
Organ Protection Program, Department of Anesthesiology, University of Colorado School of Medicine, Denver, Colorado, United States of America
Jun Han, Christoph H. Borchers
University of Victoria–Genome BC Proteomics Centre, Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada
Thomas J. Mariani
University of Rochester, Center for Pediatric Biomedical Research, Rochester, New York, United States of America
Michel Mittelbronn
Institute of Neurology (Edinger Institute), University of Frankfurt, Frankfurt, Germany

Corresponding Author

Email: holger.eltzschig@ucdenver.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TE HKE. Performed the experiments: TE KB MB TP JH CHB TJM DJK MM. Analyzed the data: TE KB MB TP JH CHB DJK MM HKE. Contributed reagents/materials/analysis tools: TP JH CHB TJM DJK MM. Wrote the paper: TE HKE.