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Research Article

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study

  • Christopher S. Carlson mail,

    ccarlson@fhcrc.org

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Tara C. Matise,

    Affiliation: Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Kari E. North,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

    X
  • Megan D. Fesinmeyer,

    Affiliation: Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, Washington, United States of America

    X
  • Steven Buyske,

    Affiliation: Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America

    X
  • Fredrick R. Schumacher,

    Affiliation: Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America

    X
  • Ulrike Peters,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Nora Franceschini,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

    X
  • Marylyn D. Ritchie,

    Affiliation: Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

    X
  • David J. Duggan,

    Affiliation: Translational Genomics Research Institute, Phoenix, Arizona, United States of America

    X
  • Kylee L. Spencer,

    Affiliation: Department of Biology & Environmental Science at Heidelberg University, Tiffin, Ohio, United States of America

    X
  • Logan Dumitrescu,

    Affiliation: Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Charles B. Eaton,

    Affiliation: Department of Family Medicine, Brown University, Pawtucket, Rhode Island, United States of America

    X
  • Fridtjof Thomas,

    Affiliation: Division of Biostatistics & Epidemiology, Department of Preventive Medicine, College of Medicine, The University of Tennessee Healthy Science Center, Memphis, Tennessee, United States of America

    X
  • Alicia Young,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Cara Carty,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • Gerardo Heiss,

    Affiliation: Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America

    X
  • Dana C. Crawford,

    Affiliation: Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America

    X
  • Lucia A. Hindorff,

    Affiliation: Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Charles L. Kooperberg,

    Affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America

    X
  • for the PAGE Consortium

    Membership of the PAGE study is provided in the Acknowledgments.

    X
  • Published: September 17, 2013
  • DOI: 10.1371/journal.pbio.1001661

About the Authors

Christopher S. Carlson, Ulrike Peters, Alicia Young, Cara Carty, Charles L. Kooperberg
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
Tara C. Matise
Department of Genetics, Rutgers University, Piscataway, New Jersey, United States of America
Kari E. North, Nora Franceschini, Gerardo Heiss
Department of Epidemiology and Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill, North Carolina, United States of America
Christopher A. Haiman, Fredrick R. Schumacher
Department of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, California, United States of America
Megan D. Fesinmeyer
Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, Seattle, Washington, United States of America
Steven Buyske
Department of Statistics & Biostatistics, Rutgers University, Piscataway, New Jersey, United States of America
Marylyn D. Ritchie
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
David J. Duggan
Translational Genomics Research Institute, Phoenix, Arizona, United States of America
Kylee L. Spencer
Department of Biology & Environmental Science at Heidelberg University, Tiffin, Ohio, United States of America
Logan Dumitrescu, Dana C. Crawford
Department of Molecular Physiology and Biophysics, Center for Human Genetics Research, Vanderbilt University, Nashville, Tennessee, United States of America
Charles B. Eaton
Department of Family Medicine, Brown University, Pawtucket, Rhode Island, United States of America
Fridtjof Thomas
Division of Biostatistics & Epidemiology, Department of Preventive Medicine, College of Medicine, The University of Tennessee Healthy Science Center, Memphis, Tennessee, United States of America
Loic Le Marchand
Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii, United States of America
Lucia A. Hindorff
Division of Genomic Medicine, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Corresponding Author

Email: ccarlson@fhcrc.org

Competing Interests

The authors have declared that no competing interests exist. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official views of the NIH, the Centers for Disease Control, the Indian Health Service, or any other funding agency.

Author Contributions

  • ¶ Membership of the PAGE study is provided in the Acknowledgments.
  • The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CSC KEN CLK DCC CAH FRS MDR UP LAH. Performed the experiments: AY KLS LD MDF DJD. Analyzed the data: NF SB CC LD MDF FRS. Contributed reagents/materials/analysis tools: FT PAGE Consortium. Wrote the paper: CSC CLK. Editorial feedback and revisions: KEN CAH MDF SB FRS UP NF MDR DJD CBE FT TCM GH LLM DCC LAH.