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Research Article

Dectin-1 Is Essential for Reverse Transcytosis of Glycosylated SIgA-Antigen Complexes by Intestinal M Cells

  • Nicolas Rochereau,

    Affiliation: GIMAP/EA3064, INSERM CIE3 Vaccinology, Université de Lyon, Saint-Etienne, France

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  • Daniel Drocourt,

    Affiliation: Cayla-InvivoGen, Toulouse, France

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  • Eric Perouzel,

    Affiliation: Cayla-InvivoGen, Toulouse, France

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  • Vincent Pavot,

    Affiliation: Institut de Biologie et Chimie des Protéines, FRE3310/CNRS, Université de Lyon, France

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  • Pierre Redelinghuys,

    Affiliation: Section of Infection and Immunity, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Gordon D. Brown,

    Affiliation: Section of Infection and Immunity, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom

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  • Gerard Tiraby,

    Affiliation: Cayla-InvivoGen, Toulouse, France

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  • Xavier Roblin,

    Affiliation: GIMAP/EA3064, INSERM CIE3 Vaccinology, Université de Lyon, Saint-Etienne, France

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  • Bernard Verrier,

    Affiliation: Institut de Biologie et Chimie des Protéines, FRE3310/CNRS, Université de Lyon, France

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  • Christian Genin,

    Affiliation: GIMAP/EA3064, INSERM CIE3 Vaccinology, Université de Lyon, Saint-Etienne, France

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  • Blaise Corthésy,

    Affiliation: R&D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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  • Stéphane Paul mail

    stephane.paul@chu-st-etienne.fr

    Affiliation: GIMAP/EA3064, INSERM CIE3 Vaccinology, Université de Lyon, Saint-Etienne, France

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  • Published: September 17, 2013
  • DOI: 10.1371/journal.pbio.1001658

About the Authors

Nicolas Rochereau, Xavier Roblin, Christian Genin, Stéphane Paul
GIMAP/EA3064, INSERM CIE3 Vaccinology, Université de Lyon, Saint-Etienne, France
Daniel Drocourt, Eric Perouzel, Gerard Tiraby
Cayla-InvivoGen, Toulouse, France
Vincent Pavot, Bernard Verrier
Institut de Biologie et Chimie des Protéines, FRE3310/CNRS, Université de Lyon, France
Pierre Redelinghuys, Gordon D. Brown
Section of Infection and Immunity, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom
Blaise Corthésy
R&D Laboratory of the Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

Corresponding Author

Email: stephane.paul@chu-st-etienne.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SP NR BC. Performed the experiments: SP NR PR GB VP. Analyzed the data: SP NR BC BV CG. Contributed reagents/materials/analysis tools: PR GB DD EP GT XR. Wrote the paper: SP NR BC.