Advertisement
Research Article

A Cullin1-Based SCF E3 Ubiquitin Ligase Targets the InR/PI3K/TOR Pathway to Regulate Neuronal Pruning

  • Jack Jing Lin Wong,

    Affiliations: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore, Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore

    X
  • Song Li equal contributor,

    equal contributor Contributed equally to this work with: Song Li, Edwin Kok Hao Lim, Yan Wang

    Affiliations: Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore, Neuroscience and Behavioral Disorder Program, Duke–NUS Graduate Medical School Singapore, Singapore

    X
  • Edwin Kok Hao Lim equal contributor,

    equal contributor Contributed equally to this work with: Song Li, Edwin Kok Hao Lim, Yan Wang

    Affiliation: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore

    X
  • Yan Wang equal contributor,

    equal contributor Contributed equally to this work with: Song Li, Edwin Kok Hao Lim, Yan Wang

    Affiliation: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore

    X
  • Cheng Wang,

    Affiliation: Neuroscience and Behavioral Disorder Program, Duke–NUS Graduate Medical School Singapore, Singapore

    X
  • Heng Zhang,

    Affiliation: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore

    X
  • Daniel Kirilly,

    Affiliation: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore

    X
  • Chunlai Wu,

    Affiliation: Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America

    X
  • Yih-Cherng Liou,

    Affiliations: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore, Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore

    X
  • Hongyan Wang,

    Affiliations: Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore, Neuroscience and Behavioral Disorder Program, Duke–NUS Graduate Medical School Singapore, Singapore, Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

    X
  • Fengwei Yu mail

    fengwei@tll.org.sg

    Affiliations: Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore, Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore, Neuroscience and Behavioral Disorder Program, Duke–NUS Graduate Medical School Singapore, Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

    X
  • Published: September 17, 2013
  • DOI: 10.1371/journal.pbio.1001657

About the Authors

Jack Jing Lin Wong, Edwin Kok Hao Lim, Yan Wang, Heng Zhang, Daniel Kirilly, Yih-Cherng Liou, Fengwei Yu
Temasek Life Sciences Laboratory and Department of Biological Sciences, National University of Singapore, Singapore
Jack Jing Lin Wong, Song Li, Yih-Cherng Liou, Hongyan Wang, Fengwei Yu
Graduate School for Integrated Sciences and Engineering, Centre for Life Sciences, National University of Singapore (NUS), Singapore
Song Li, Cheng Wang, Hongyan Wang, Fengwei Yu
Neuroscience and Behavioral Disorder Program, Duke–NUS Graduate Medical School Singapore, Singapore
Chunlai Wu
Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America
Hongyan Wang
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Fengwei Yu
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

Corresponding Author

Email: fengwei@tll.org.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JW SL HW FY. Performed the experiments: JW SL EL YW CWa HZ DK. Analyzed the data: JW SL YL HW FY. Contributed reagents/materials/analysis tools: CWu HW FY. Wrote the paper: JW FY.