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Research Article

Integrated Conformational and Lipid-Sensing Regulation of Endosomal ArfGEF BRAG2

  • Kaheina Aizel,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Valérie Biou,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Jorge Navaza,

    Affiliations: Institut de Biologie Structurale, CNRS/CEA/Université Joseph Fourier, Grenoble, France, Unidad de Biofísica CSIC-UPV/EHU, Leioa, Bizkaia, Spain

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  • Lionel V. Duarte,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Valérie Campanacci,

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Jacqueline Cherfils mail,

    cherfils@lebs.cnrs-gif.fr (JC); zeghouf@lebs.cnrs-gif.fr (MZ)

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Mahel Zeghouf mail

    cherfils@lebs.cnrs-gif.fr (JC); zeghouf@lebs.cnrs-gif.fr (MZ)

    Affiliation: Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France

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  • Published: September 10, 2013
  • DOI: 10.1371/journal.pbio.1001652

About the Authors

Kaheina Aizel, Valérie Biou, Lionel V. Duarte, Valérie Campanacci, Jacqueline Cherfils, Mahel Zeghouf
Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Gif-sur-Yvette, France
Jorge Navaza
Institut de Biologie Structurale, CNRS/CEA/Université Joseph Fourier, Grenoble, France
Jorge Navaza
Unidad de Biofísica CSIC-UPV/EHU, Leioa, Bizkaia, Spain

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JC MZ. Performed the experiments: KA VB LD VC MZ. Analyzed the data: KA VB JN VC JC MZ. Wrote the paper: JC. Prepared the figures: KA LD VC JC MZ.