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Research Article

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

  • Thomas L. Rodgers equal contributor,

    equal contributor Contributed equally to this work with: Thomas L. Rodgers, Philip D. Townsend

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom

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  • Philip D. Townsend equal contributor,

    equal contributor Contributed equally to this work with: Thomas L. Rodgers, Philip D. Townsend

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom

    X
  • David Burnell,

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom

    X
  • Matthew L. Jones,

    Affiliation: Department of Physics, Durham University, Durham, United Kingdom

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  • Shane A. Richards,

    Affiliation: School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom

    X
  • Tom C. B. McLeish,

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom, Department of Physics, Durham University, Durham, United Kingdom

    X
  • Ehmke Pohl,

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom

    X
  • Mark R. Wilson,

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, Department of Chemistry, Durham University, Durham, United Kingdom

    X
  • Martin J. Cann mail

    m.j.cann@durham.ac.uk

    Affiliations: Biophysical Sciences Institute, Durham University, Durham, United Kingdom, School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom

    X
  • Published: September 10, 2013
  • DOI: 10.1371/journal.pbio.1001651

About the Authors

Thomas L. Rodgers, Philip D. Townsend, David Burnell, Tom C. B. McLeish, Ehmke Pohl, Mark R. Wilson, Martin J. Cann
Biophysical Sciences Institute, Durham University, Durham, United Kingdom
Thomas L. Rodgers, David Burnell, Tom C. B. McLeish, Ehmke Pohl, Mark R. Wilson
Department of Chemistry, Durham University, Durham, United Kingdom
Philip D. Townsend, Shane A. Richards, Ehmke Pohl, Martin J. Cann
School of Biological and Biomedical Sciences, Durham University, Durham, United Kingdom
Matthew L. Jones, Tom C. B. McLeish
Department of Physics, Durham University, Durham, United Kingdom

Corresponding Author

Email: m.j.cann@durham.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TCBM EP MRW MJC. Performed the experiments: TLR PDT DB MLJ. Analyzed the data: TLR PDT SAR EP. Wrote the paper: TCBM MRW MJC.