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Research Article

The HILDA Complex Coordinates a Conditional Switch in the 3′-Untranslated Region of the VEGFA mRNA

  • Peng Yao,

    Affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Alka A. Potdar,

    Affiliations: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America

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  • Partho Sarothi Ray,

    Affiliation: Department of Biology, Indian Institute of Science Education and Research, Kolkata, India

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  • Sandeepa M. Eswarappa,

    Affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Andrew C. Flagg,

    Affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Belinda Willard,

    Affiliation: Mass Spectrometry Laboratory for Protein Sequencing, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Paul L. Fox mail

    foxp@ccf.org

    Affiliation: Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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  • Published: August 20, 2013
  • DOI: 10.1371/journal.pbio.1001635

About the Authors

Peng Yao, Alka A. Potdar, Sandeepa M. Eswarappa, Andrew C. Flagg, Paul L. Fox
Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Alka A. Potdar
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America
Partho Sarothi Ray
Department of Biology, Indian Institute of Science Education and Research, Kolkata, India
Belinda Willard
Mass Spectrometry Laboratory for Protein Sequencing, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

Corresponding Author

Email: foxp@ccf.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: PY AAP PSR SME PLF. Performed the experiments: PY SME ACF BW. Analyzed the data: PY AAP SME PLF. Wrote the paper: PY AAP PSR PLF.