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Research Article

Developmental Changes in the in Vitro Activated Regenerative Activity of Primitive Mammary Epithelial Cells

  • Maisam Makarem,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Nagarajan Kannan,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Long V. Nguyen,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • David J. H. F. Knapp,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Sneha Balani,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Michael D. Prater,

    Affiliation: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom

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  • John Stingl,

    Affiliation: Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom

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  • Afshin Raouf,

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, Department of Immunology and The Regenerative Medicine Program, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada

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  • Oksana Nemirovsky,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Peter Eirew,

    Affiliation: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada

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  • Connie J. Eaves mail

    ceaves@bccrc.ca

    Affiliations: Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, Departments of Medical Genetics, Medicine, and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: August 13, 2013
  • DOI: 10.1371/journal.pbio.1001630

About the Authors

Maisam Makarem, Nagarajan Kannan, Long V. Nguyen, David J. H. F. Knapp, Sneha Balani, Afshin Raouf, Oksana Nemirovsky, Peter Eirew, Connie J. Eaves
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
Michael D. Prater, John Stingl
Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, United Kingdom
Afshin Raouf
Department of Immunology and The Regenerative Medicine Program, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
Connie J. Eaves
Departments of Medical Genetics, Medicine, and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: ceaves@bccrc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CJE MM. Performed the experiments: MM NK. Analyzed the data: CJE MM NK LVN DJHFK SB. Contributed reagents/materials/analysis tools: JS MDP ON AR PE. Wrote the paper: CJE MM.