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Research Article

MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

  • Helena Bujalka equal contributor,

    equal contributor Contributed equally to this work with: Helena Bujalka, Matthias Koenning

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Matthias Koenning equal contributor,

    equal contributor Contributed equally to this work with: Helena Bujalka, Matthias Koenning

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Stacey Jackson,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

    X
  • Victoria M. Perreau,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Bernard Pope,

    Affiliation: Department of Computing and Information Systems and Victorian Life Sciences Computation Initiative (VLSCI), University of Melbourne, Parkville, Australia

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  • Curtis M. Hay,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Stanlislaw Mitew,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Andrew F. Hill,

    Affiliation: Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia

    X
  • Q. Richard Lu,

    Affiliation: Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas at Austin, Austin, Texas, United States of America

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  • Michael Wegner,

    Affiliation: Institute for Biochemistry, University Erlangen-Nuernberg, Germany

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  • Rajini Srinivasan,

    Affiliation: Waisman Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • John Svaren,

    Affiliation: Waisman Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Melanie Willingham,

    Affiliation: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia

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  • Ben A. Barres,

    Affiliation: Department of Neurobiology, Stanford University, Stanford, California, United States of America

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  • Ben Emery mail

    emeryb@unimelb.edu.au

    Affiliations: Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia, Florey Institute of Neuroscience and Mental Health, Parkville, Australia

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  • Published: August 13, 2013
  • DOI: 10.1371/journal.pbio.1001625

About the Authors

Helena Bujalka, Matthias Koenning, Stacey Jackson, Victoria M. Perreau, Curtis M. Hay, Stanlislaw Mitew, Melanie Willingham, Ben Emery
Department of Anatomy and Neuroscience and the Centre for Neuroscience Research, University of Melbourne, Parkville, Australia
Bernard Pope
Department of Computing and Information Systems and Victorian Life Sciences Computation Initiative (VLSCI), University of Melbourne, Parkville, Australia
Andrew F. Hill
Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Australia
Q. Richard Lu
Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas at Austin, Austin, Texas, United States of America
Michael Wegner
Institute for Biochemistry, University Erlangen-Nuernberg, Germany
Rajini Srinivasan, John Svaren
Waisman Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America
Ben A. Barres
Department of Neurobiology, Stanford University, Stanford, California, United States of America
Ben Emery
Florey Institute of Neuroscience and Mental Health, Parkville, Australia

Corresponding Author

Email: emeryb@unimelb.edu.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HB MK VMP AFH BAB BE. Performed the experiments: HB MK SJ VMP BP SM CMH RS MWi BE. Analyzed the data: HB MK VMP BP BE. Contributed reagents/materials/analysis tools: JS MWe QRL. Wrote the paper: HB MK VMP BE.