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Research Article

Stochastic Cytokine Expression Induces Mixed T Helper Cell States

  • Miaoqing Fang,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Huangming Xie,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

    Current address: Division of Newborn Medicine, Department of Medicine, Children's Hospital Boston, Boston, Massachusetts, United States of America.

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  • Stephanie K. Dougan,

    Affiliation: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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  • Hidde Ploegh,

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Alexander van Oudenaarden mail

    a.vanoudenaarden@hubrecht.eu

    Affiliations: Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands

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  • Published: July 30, 2013
  • DOI: 10.1371/journal.pbio.1001618

About the Authors

Miaoqing Fang
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Miaoqing Fang, Alexander van Oudenaarden
Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Huangming Xie, Stephanie K. Dougan, Hidde Ploegh
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Hidde Ploegh, Alexander van Oudenaarden
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Alexander van Oudenaarden
Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center Utrecht, Utrecht, The Netherlands

Corresponding Author

Email: a.vanoudenaarden@hubrecht.eu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MF AvO. Performed the experiments: MF. Analyzed the data: MF. Contributed reagents/materials/analysis tools: HX SKD HP. Wrote the paper: MF AvO.