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Research Article

Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

  • Yaron E. Antebi equal contributor,

    equal contributor Contributed equally to this work with: Yaron E. Antebi, Shlomit Reich-Zeliger

    Affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    Current address: Division of Biology, California Institute of Technology, Pasadena, California, United States of America

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  • Shlomit Reich-Zeliger equal contributor,

    equal contributor Contributed equally to this work with: Yaron E. Antebi, Shlomit Reich-Zeliger

    Affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Yuval Hart,

    Affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Avi Mayo,

    Affiliation: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Inbal Eizenberg,

    Affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Jacob Rimer,

    Affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Prabhakar Putheti,

    Affiliation: Transplantation Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medical Center, New York, New York, United States of America

    X
  • Dana Pe'er,

    Affiliation: Department of Biological Sciences, Columbia University, New York, New York, United States of America

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  • Nir Friedman mail

    nir.friedman@weizmann.ac.il

    Affiliation: Department of Immunology, Weizmann Institute of Science, Rehovot, Israel

    X
  • Published: July 30, 2013
  • DOI: 10.1371/journal.pbio.1001616

About the Authors

Yaron E. Antebi, Shlomit Reich-Zeliger, Inbal Eizenberg, Jacob Rimer, Nir Friedman
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
Yuval Hart, Avi Mayo
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
Prabhakar Putheti
Transplantation Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
Dana Pe'er
Department of Biological Sciences, Columbia University, New York, New York, United States of America

Corresponding Author

Email: nir.friedman@weizmann.ac.il

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YEA SRZ NF. Performed the experiments: YEA SRZ IE. Analyzed the data: YEA SRZ YH AM IE JR. Contributed reagents/materials/analysis tools: PP DP. Wrote the paper: YEA NF. Mathematical modeling: YEA YH AM.