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Research Article

Production of α-Galactosylceramide by a Prominent Member of the Human Gut Microbiota

  • Laura C. Wieland Brown equal contributor,

    equal contributor Contributed equally to this work with: Laura C. Wieland Brown, Cristina Penaranda

    Affiliations: Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Cristina Penaranda equal contributor,

    equal contributor Contributed equally to this work with: Laura C. Wieland Brown, Cristina Penaranda

    Affiliation: Diabetes Center and the Department of Medicine, University of California, San Francisco, California, United States of America

    X
  • Purna C. Kashyap,

    Affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Brianna B. Williams,

    Affiliation: Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America

    X
  • Jon Clardy,

    Affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Mitchell Kronenberg,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

    X
  • Justin L. Sonnenburg,

    Affiliation: Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America

    X
  • Laurie E. Comstock,

    Affiliation: Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Jeffrey A. Bluestone mail,

    jeffreya.bluestone@ucsf.edu (JAB); fischbach@fischbachgroup.org (MAF)

    Affiliation: Diabetes Center and the Department of Medicine, University of California, San Francisco, California, United States of America

    X
  • Michael A. Fischbach mail

    jeffreya.bluestone@ucsf.edu (JAB); fischbach@fischbachgroup.org (MAF)

    Affiliation: Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America

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  • Published: July 16, 2013
  • DOI: 10.1371/journal.pbio.1001610

About the Authors

Laura C. Wieland Brown, Brianna B. Williams, Michael A. Fischbach
Department of Bioengineering and Therapeutic Sciences and the California Institute for Quantitative Biosciences, University of California, San Francisco, California, United States of America
Laura C. Wieland Brown, Jon Clardy
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America
Cristina Penaranda, Jeffrey A. Bluestone
Diabetes Center and the Department of Medicine, University of California, San Francisco, California, United States of America
Purna C. Kashyap, Justin L. Sonnenburg
Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, United States of America
Mitchell Kronenberg
La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
Laurie E. Comstock
Division of Infectious Diseases, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LCB CP PCK BBW JC MK JLS LEC JAB MAF. Performed the experiments: LCB CP PCK BBW. Analyzed the data: LCB CP PCK BBW JC MK JLS LEC JAB MAF. Wrote the paper: LCB CP JAB MAF.