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Research Article

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

  • Carsten Frühbeis equal contributor,

    equal contributor Contributed equally to this work with: Carsten Frühbeis, Dominik Fröhlich

    Affiliation: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany

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  • Dominik Fröhlich equal contributor,

    equal contributor Contributed equally to this work with: Carsten Frühbeis, Dominik Fröhlich

    Affiliation: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany

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  • Wen Ping Kuo,

    Affiliations: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany, Focus Program Translational Neuroscience, University of Mainz, Mainz, Germany

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  • Jesa Amphornrat,

    Affiliation: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany

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  • Sebastian Thilemann,

    Affiliation: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany

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  • Aiman S. Saab,

    Affiliations: Max Planck Institute of Experimental Medicine, Göttingen, Germany, Department of Molecular Physiology, University of Saarland, Homburg, Germany

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  • Frank Kirchhoff,

    Affiliations: Max Planck Institute of Experimental Medicine, Göttingen, Germany, Department of Molecular Physiology, University of Saarland, Homburg, Germany

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  • Wiebke Möbius,

    Affiliation: Max Planck Institute of Experimental Medicine, Göttingen, Germany

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  • Sandra Goebbels,

    Affiliation: Max Planck Institute of Experimental Medicine, Göttingen, Germany

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  • Klaus-Armin Nave,

    Affiliation: Max Planck Institute of Experimental Medicine, Göttingen, Germany

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  • Anja Schneider,

    Affiliation: Department of Psychiatry and Psychotherapy, University of Göttingen, German Center for Neurodegenerative Diseases, DZNE Goettingen, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain (EXC171) and DFG Research Center of Molecular Physiology of the Brain, Göttingen, Germany

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  • Mikael Simons,

    Affiliations: Max Planck Institute of Experimental Medicine, Göttingen, Germany, Department of Neurology, University of Göttingen, Göttingen, Germany

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  • Matthias Klugmann,

    Affiliation: Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, Australia

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  • Jacqueline Trotter,

    Affiliations: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany, Focus Program Translational Neuroscience, University of Mainz, Mainz, Germany

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  • Eva-Maria Krämer-Albers mail

    emkraemer@uni-mainz.de

    Affiliations: Department of Molecular Cell Biology, University of Mainz, Mainz, Germany, Focus Program Translational Neuroscience, University of Mainz, Mainz, Germany

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  • Published: July 09, 2013
  • DOI: 10.1371/journal.pbio.1001604

About the Authors

Carsten Frühbeis, Dominik Fröhlich, Wen Ping Kuo, Jesa Amphornrat, Sebastian Thilemann, Jacqueline Trotter, Eva-Maria Krämer-Albers
Department of Molecular Cell Biology, University of Mainz, Mainz, Germany
Wen Ping Kuo, Jacqueline Trotter, Eva-Maria Krämer-Albers
Focus Program Translational Neuroscience, University of Mainz, Mainz, Germany
Aiman S. Saab, Frank Kirchhoff, Wiebke Möbius, Sandra Goebbels, Klaus-Armin Nave, Mikael Simons
Max Planck Institute of Experimental Medicine, Göttingen, Germany
Aiman S. Saab, Frank Kirchhoff
Department of Molecular Physiology, University of Saarland, Homburg, Germany
Anja Schneider
Department of Psychiatry and Psychotherapy, University of Göttingen, German Center for Neurodegenerative Diseases, DZNE Goettingen, Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain (EXC171) and DFG Research Center of Molecular Physiology of the Brain, Göttingen, Germany
Mikael Simons
Department of Neurology, University of Göttingen, Göttingen, Germany
Matthias Klugmann
Translational Neuroscience Facility, Department of Physiology, School of Medical Sciences, University of New South Wales, Sydney, Australia

Corresponding Author

Email: emkraemer@uni-mainz.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CF DF WPK EMKA. Performed the experiments: CF DF WPK JA ST WM SG AS. Analyzed the data: CF DF WPK WM SG AS EMKA. Contributed reagents/materials/analysis tools: FK ASS KAN MS MK JT. Wrote the paper: CF DF WPK EMKA. Corrected the manuscript: JT MS. Conceived and conducted the study: EMKA.