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Research Article

Effects of Resveratrol and SIRT1 on PGC-1α Activity and Mitochondrial Biogenesis: A Reevaluation

  • Kazuhiko Higashida equal contributor,

    equal contributor Contributed equally to this work with: Kazuhiko Higashida, Sang Hyun Kim

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Sang Hyun Kim equal contributor,

    equal contributor Contributed equally to this work with: Kazuhiko Higashida, Sang Hyun Kim

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Su Ryun Jung,

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Meiko Asaka,

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • John O. Holloszy mail,

    jhollosz@dom.wustl.edu

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Dong-Ho Han

    Affiliation: Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

    X
  • Published: July 09, 2013
  • DOI: 10.1371/journal.pbio.1001603

About the Authors

Kazuhiko Higashida, Sang Hyun Kim, Su Ryun Jung, Meiko Asaka, John O. Holloszy, Dong-Ho Han
Division of Geriatrics and Nutritional Sciences, Department of Medicine, Washington University School of Medicine in St. Louis, Missouri, United States of America

Corresponding Author

Email: jhollosz@dom.wustl.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JOH DHH. Performed the experiments: KH SHK SRJ MA DHH. Analyzed the data: JOH DHH KH. Wrote the paper: JOH DHH.