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Research Article

Single Cell Visualization of Yeast Gene Expression Shows Correlation of Epigenetic Switching between Multiple Heterochromatic Regions through Multiple Generations

  • Yasunobu Mano,

    Affiliations: Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan, Research Fellow of the Japan Society for the Promotion of Science, Tokyo, Japan

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  • Tetsuya J. Kobayashi,

    Affiliations: Institute of Industrial Science, The University of Tokyo, Tokyo, Japan, PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan

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  • Jun-ichi Nakayama,

    Affiliations: Laboratory for Chromatin Dynamics, Center for Developmental Biology, RIKEN, Kobe, Japan, Graduate School of Natural Sciences, Nagoya City University, Nagoya, Japan

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  • Hiroyuki Uchida,

    Affiliation: Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan

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  • Masaya Oki mail

    ma4sa6ya@u-fukui.ac.jp

    Affiliations: Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan, PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan, Research and Education Program for Life Science, University of Fukui, Fukui, Japan

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  • Published: July 02, 2013
  • DOI: 10.1371/journal.pbio.1001601

About the Authors

Yasunobu Mano, Hiroyuki Uchida, Masaya Oki
Department of Applied Chemistry and Biotechnology, Graduate School of Engineering, University of Fukui, Fukui, Japan
Yasunobu Mano
Research Fellow of the Japan Society for the Promotion of Science, Tokyo, Japan
Tetsuya J. Kobayashi
Institute of Industrial Science, The University of Tokyo, Tokyo, Japan
Tetsuya J. Kobayashi, Masaya Oki
PRESTO, Japan Science and Technology Agency (JST), Saitama, Japan
Jun-ichi Nakayama
Laboratory for Chromatin Dynamics, Center for Developmental Biology, RIKEN, Kobe, Japan
Jun-ichi Nakayama
Graduate School of Natural Sciences, Nagoya City University, Nagoya, Japan
Masaya Oki
Research and Education Program for Life Science, University of Fukui, Fukui, Japan

Corresponding Author

Email: ma4sa6ya@u-fukui.ac.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YM TK JN HU MO. Performed the experiments: YM TK MO. Analyzed the data: YM TK JN HU MO. Contributed reagents/materials/analysis tools: YM TK JN HU MO. Wrote the paper: YM TK MO.