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Research Article

Ground State Destabilization by Anionic Nucleophiles Contributes to the Activity of Phosphoryl Transfer Enzymes

  • Logan D. Andrews,

    Affiliation: Department of Chemical and Systems Biology, Stanford University, Stanford, California, United States of America

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  • Tim D. Fenn,

    Affiliation: Department of Bioengineering, Stanford University, Stanford, California, United States of America

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  • Daniel Herschlag mail

    herschla@stanford.edu

    Affiliations: Department of Chemical and Systems Biology, Stanford University, Stanford, California, United States of America, Department of Biochemistry, Stanford University, Stanford, California, United States of America

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  • Published: July 02, 2013
  • DOI: 10.1371/journal.pbio.1001599

About the Authors

Logan D. Andrews, Daniel Herschlag
Department of Chemical and Systems Biology, Stanford University, Stanford, California, United States of America
Tim D. Fenn
Department of Bioengineering, Stanford University, Stanford, California, United States of America
Daniel Herschlag
Department of Biochemistry, Stanford University, Stanford, California, United States of America

Corresponding Author

Email: herschla@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LDA DH. Performed the experiments: LDA. Analyzed the data: LDA. Wrote the paper: LDA DH. Analyzed and refined crystallographic data: TDF.