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Research Article

NKT Cell-TCR Expression Activates Conventional T Cells in Vivo, but Is Largely Dispensable for Mature NKT Cell Biology

  • J. Christoph Vahl,

    Affiliation: Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Klaus Heger,

    Affiliation: Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Nathalie Knies,

    Affiliation: Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany

    Current address: Institut für Klinische Chemie und Pathobiochemie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.

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  • Marco Y. Hein,

    Affiliation: Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany

    Current address: Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Martinsried, Germany.

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  • Louis Boon,

    Affiliation: Bioceros, Yalelaan 46, Utrecht, The Netherlands

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  • Hideo Yagita,

    Affiliation: Juntendo University School of Medicine, Tokyo, Japan

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  • Bojan Polic,

    Affiliation: University of Rijeka School of Medicine, Rijeka, Croatia

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  • Marc Schmidt-Supprian mail

    supprian@biochem.mpg.de

    Affiliation: Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany

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  • Published: June 18, 2013
  • DOI: 10.1371/journal.pbio.1001589

About the Authors

J. Christoph Vahl, Klaus Heger, Nathalie Knies, Marco Y. Hein, Marc Schmidt-Supprian
Molecular Immunology and Signaltransduction, Max Planck Institute of Biochemistry, Martinsried, Germany
Louis Boon
Bioceros, Yalelaan 46, Utrecht, The Netherlands
Hideo Yagita
Juntendo University School of Medicine, Tokyo, Japan
Bojan Polic
University of Rijeka School of Medicine, Rijeka, Croatia

Corresponding Author

Email: supprian@biochem.mpg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JCV MSS. Performed the experiments: JCV KH NK MSS. Analyzed the data: JCV MYH MSS. Contributed reagents/materials/analysis tools: LB HY BP. Wrote the paper: JCV MSS.