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Research Article

PKCβ Phosphorylates PI3Kγ to Activate It and Release It from GPCR Control

  • Romy Walser,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • John E. Burke,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Elena Gogvadze,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Thomas Bohnacker,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Xuxiao Zhang,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Daniel Hess,

    Affiliation: Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland

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  • Peter Küenzi,

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Michael Leitges,

    Affiliation: Biotechnology Centre, University of Oslo, Oslo, Norway

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  • Emilio Hirsch,

    Affiliation: Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy

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  • Roger L. Williams,

    Affiliation: Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom

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  • Muriel Laffargue,

    Affiliation: INSERM, UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France

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  • Matthias P. Wymann mail

    Matthias.Wymann@UniBas.CH

    Affiliation: Department of Biomedicine, University of Basel, Basel, Switzerland

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  • Published: June 25, 2013
  • DOI: 10.1371/journal.pbio.1001587

About the Authors

Romy Walser, Elena Gogvadze, Thomas Bohnacker, Peter Küenzi, Matthias P. Wymann
Department of Biomedicine, University of Basel, Basel, Switzerland
John E. Burke, Xuxiao Zhang, Roger L. Williams
Medical Research Council, Laboratory of Molecular Biology, Cambridge, United Kingdom
Daniel Hess
Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
Michael Leitges
Biotechnology Centre, University of Oslo, Oslo, Norway
Emilio Hirsch
Department of Genetics, Biology and Biochemistry, University of Torino, Torino, Italy
Muriel Laffargue
INSERM, UMR1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France

Corresponding Author

Email: Matthias.Wymann@UniBas.CH

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RW JEB EG TB RLW MPW. Performed the experiments: RW JEB EG TB XZ DH PK MuL MPW. Analyzed the data: RW JEB EG TB DH RLW MPW. Contributed reagents/materials/analysis tools: MiL EH. Wrote the paper: RW JEB EG TB RLW MPW.