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Research Article

Molecular Remodeling of Tip Links Underlies Mechanosensory Regeneration in Auditory Hair Cells

  • Artur A. Indzhykulian,

    Affiliation: Department of Physiology, University of Kentucky, Lexington, Kentucky, United States of America

    Current address: Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ruben Stepanyan,

    Affiliation: Department of Physiology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Anastasiia Nelina,

    Affiliation: Department of Physiology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Kateri J. Spinelli,

    Affiliation: Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Zubair M. Ahmed,

    Affiliation: Division of Pediatric Ophthalmology, Cincinnati Children's Research Foundation, Cincinnati, Ohio, United States of America

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  • Inna A. Belyantseva,

    Affiliation: Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

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  • Thomas B. Friedman,

    Affiliation: Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

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  • Peter G. Barr-Gillespie,

    Affiliation: Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, United States of America

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  • Gregory I. Frolenkov mail

    Gregory.Frolenkov@uky.edu

    Affiliation: Department of Physiology, University of Kentucky, Lexington, Kentucky, United States of America

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  • Published: June 11, 2013
  • DOI: 10.1371/journal.pbio.1001583

About the Authors

Artur A. Indzhykulian, Ruben Stepanyan, Anastasiia Nelina, Gregory I. Frolenkov
Department of Physiology, University of Kentucky, Lexington, Kentucky, United States of America
Kateri J. Spinelli, Peter G. Barr-Gillespie
Oregon Hearing Research Center, Oregon Health & Science University, Portland, Oregon, United States of America
Zubair M. Ahmed
Division of Pediatric Ophthalmology, Cincinnati Children's Research Foundation, Cincinnati, Ohio, United States of America
Inna A. Belyantseva, Thomas B. Friedman
Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, Maryland, United States of America

Corresponding Author

Email: Gregory.Frolenkov@uky.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GIF AAI. Performed the experiments: AAI RS AN KJS PGB-G GIF. Analyzed the data: AAI RS GIF. Contributed reagents/materials/analysis tools: ZMA IAB TBF KJS PGB-G. Wrote the paper: AAI GIF. Developed a novel immuno-SEM technique: GIF AAI IAB TBF.