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Research Article

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

  • Smarajit Polley equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • De-Bin Huang equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Arthur V. Hauenstein equal contributor,

    equal contributor Contributed equally to this work with: Smarajit Polley, De-Bin Huang, Arthur V. Hauenstein

    Affiliation: Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, San Diego, California, United States of America

    X
  • Amanda J. Fusco,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Xiangyang Zhong,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Don Vu,

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Bärbel Schröfelbauer,

    Affiliations: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America, Signaling Systems Laboratory, University of California–San Diego, La Jolla, California, United States of America

    X
  • Youngchang Kim,

    Affiliation: Argonne National Laboratory, Argonne, Illinois, United States of America

    X
  • Alexander Hoffmann,

    Affiliations: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America, Signaling Systems Laboratory, University of California–San Diego, La Jolla, California, United States of America

    X
  • Inder M. Verma,

    Affiliation: Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, United States of America

    X
  • Gourisankar Ghosh mail,

    gghosh@ucsd.edu (GG); thuxford@mail.sdsu.edu (TH)

    Affiliation: Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America

    X
  • Tom Huxford mail

    gghosh@ucsd.edu (GG); thuxford@mail.sdsu.edu (TH)

    Affiliation: Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, San Diego, California, United States of America

    X
  • Published: June 11, 2013
  • DOI: 10.1371/journal.pbio.1001581

About the Authors

Smarajit Polley, De-Bin Huang, Amanda J. Fusco, Xiangyang Zhong, Don Vu, Bärbel Schröfelbauer, Alexander Hoffmann, Gourisankar Ghosh
Department of Chemistry & Biochemistry, University of California–San Diego, La Jolla, California, United States of America
Arthur V. Hauenstein, Tom Huxford
Structural Biochemistry Laboratory, Department of Chemistry & Biochemistry, San Diego State University, San Diego, California, United States of America
Bärbel Schröfelbauer, Alexander Hoffmann
Signaling Systems Laboratory, University of California–San Diego, La Jolla, California, United States of America
Youngchang Kim
Argonne National Laboratory, Argonne, Illinois, United States of America
Inder M. Verma
Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SP AVH AH IMV GG TH. Performed the experiments: SP DH AVH AJF XZ DV BS YK. Analyzed the data: SP DH AVH YK AH GG TH. Contributed reagents/materials/analysis tools: SP DH AVH AJF XZ DV BS YK. Wrote the paper: SP AVH GG TH.