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Research Article

PICK1 Deficiency Impairs Secretory Vesicle Biogenesis and Leads to Growth Retardation and Decreased Glucose Tolerance

  • Birgitte Holst equal contributor mail,

    equal contributor Contributed equally to this work with: Birgitte Holst, Kenneth L. Madsen

    holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

    Affiliations: Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Kenneth L. Madsen equal contributor,

    equal contributor Contributed equally to this work with: Birgitte Holst, Kenneth L. Madsen

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Anna M. Jansen,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Chunyu Jin,

    Affiliations: Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Mattias Rickhag,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Viktor K. Lund,

    Affiliation: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Morten Jensen,

    Affiliations: Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Vikram Bhatia,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, BioNano Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Gunnar Sørensen,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Andreas N. Madsen,

    Affiliations: Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Zhichao Xue,

    Affiliations: Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

    X
  • Siri K. Møller,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

    X
  • David Woldbye,

    Affiliation: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

    X
  • Klaus Qvortrup,

    Affiliation: Core Facility for Integrated Microscopy, Department of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

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  • Richard Huganir,

    Affiliation: Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

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  • Dimitrios Stamou,

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, BioNano Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

    X
  • Ole Kjærulff mail,

    holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

    Affiliation: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

    X
  • Ulrik Gether mail

    holst@sund.ku.dk (BH); okjaerulff@sund.ku.dk (OK); gether@sund.ku.dk (UG)

    Affiliations: Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark, Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark

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  • Published: April 23, 2013
  • DOI: 10.1371/journal.pbio.1001542

About the Authors

Birgitte Holst, Chunyu Jin, Morten Jensen, Andreas N. Madsen, Zhichao Xue
Laboratory for Molecular Pharmacology, Novo Nordisk Foundation Center for Basic Metabolic Research, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
Birgitte Holst, Kenneth L. Madsen, Anna M. Jansen, Chunyu Jin, Mattias Rickhag, Viktor K. Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N. Madsen, Zhichao Xue, Siri K. Møller, David Woldbye, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether
Department of Neuroscience and Pharmacology, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
Kenneth L. Madsen, Anna M. Jansen, Mattias Rickhag, Gunnar Sørensen, Siri K. Møller, Ulrik Gether
Molecular Neuropharmacology Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
Vikram Bhatia, Dimitrios Stamou
BioNano Laboratory, The Faculty of Health Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark
Klaus Qvortrup
Core Facility for Integrated Microscopy, Department of Biomedical Science, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Richard Huganir
Department of Neuroscience, The Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BH KLM AMJ OK UG. Performed the experiments: BH KLM AMJ CJ MR VKL MJ VB GS ANM ZX SKM. Analyzed the data: BH KLM AMJ CJ MR VKL KQ OK UG. Contributed reagents/materials/analysis tools: DW KQ RH DS. Wrote the paper: BH KLM OK UG.