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Research Article

PICK1 and ICA69 Control Insulin Granule Trafficking and Their Deficiencies Lead to Impaired Glucose Tolerance

  • Mian Cao equal contributor,

    equal contributor Contributed equally to this work with: Mian Cao, Zhuo Mao

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

    Current address: Department of Cell Biology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, United States of America

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  • Zhuo Mao equal contributor,

    equal contributor Contributed equally to this work with: Mian Cao, Zhuo Mao

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Chuen Kam,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Nan Xiao,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Xiaoxing Cao,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Chong Shen,

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Kenneth K. Y. Cheng,

    Affiliation: Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China

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  • Aimin Xu,

    Affiliation: Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China

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  • Kwong-Man Lee,

    Affiliation: Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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  • Liwen Jiang,

    Affiliation: School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China

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  • Jun Xia mail

    jxia@ust.hk

    Affiliation: Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China

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  • Published: April 23, 2013
  • DOI: 10.1371/journal.pbio.1001541

About the Authors

Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Jun Xia
Division of Life Science, Division of Biomedical Engineering and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong, China
Kenneth K. Y. Cheng, Aimin Xu
Department of Medicine and Department of Pharmacology & Pharmacy, University of Hong Kong, Hong Kong, China
Kwong-Man Lee
Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
Liwen Jiang
School of Life Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, China

Corresponding Author

Email: jxia@ust.hk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MC ZM JX. Performed the experiments: MC ZM CK NX XC CS. Analyzed the data: MC ZM CK KC AX JX. Contributed reagents/materials/analysis tools: KML LJ AX. Wrote the paper: MC ZM KC JX.