Advertisement
Research Article

When the Most Potent Combination of Antibiotics Selects for the Greatest Bacterial Load: The Smile-Frown Transition

  • Rafael Pena-Miller,

    Affiliation: Biosciences, Geoffrey Pope Building, University of Exeter, United Kingdom

    X
  • David Laehnemann,

    Affiliation: Evolutionary Ecology and Genetics, Zoological Institute, CAU Kiel, Kiel, Germany

    X
  • Gunther Jansen,

    Affiliation: Evolutionary Ecology and Genetics, Zoological Institute, CAU Kiel, Kiel, Germany

    X
  • Ayari Fuentes-Hernandez,

    Affiliation: Biosciences, Geoffrey Pope Building, University of Exeter, United Kingdom

    X
  • Philip Rosenstiel,

    Affiliation: Institute for Clinical Molecular Biology, CAU Kiel, Kiel, Germany

    X
  • Hinrich Schulenburg,

    Affiliation: Evolutionary Ecology and Genetics, Zoological Institute, CAU Kiel, Kiel, Germany

    X
  • Robert Beardmore mail

    r.e.beardmore@exeter.ac.uk

    Affiliation: Biosciences, Geoffrey Pope Building, University of Exeter, United Kingdom

    X
  • Published: April 23, 2013
  • DOI: 10.1371/journal.pbio.1001540

About the Authors

Rafael Pena-Miller, Ayari Fuentes-Hernandez, Robert Beardmore
Biosciences, Geoffrey Pope Building, University of Exeter, United Kingdom
David Laehnemann, Gunther Jansen, Hinrich Schulenburg
Evolutionary Ecology and Genetics, Zoological Institute, CAU Kiel, Kiel, Germany
Philip Rosenstiel
Institute for Clinical Molecular Biology, CAU Kiel, Kiel, Germany

Corresponding Author

Email: r.e.beardmore@exeter.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: REB HS RPM DL AFH GJ. Performed the experiments: DL GJ AFH RPM. Analyzed the data: REB RPM GJ DL PR. Contributed reagents/materials/analysis tools: REB HS PR. Wrote the paper: REB HS RPM GJ.