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Research Article

A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta

  • Jinhua Lu,

    Affiliations: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Shuang Zhang,

    Affiliations: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Haruo Nakano,

    Affiliation: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

    Current address: Innovative Drug Research Laboratories, Kyowa Hakko Kirin Co., Ltd., Tokyo, Japan

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  • David G. Simmons,

    Affiliation: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

    Current address: School of Biomedical Sciences, The University of Queensland, St. Lucia, Queensland, Australia

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  • Shumin Wang,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Shuangbo Kong,

    Affiliations: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Qiang Wang,

    Affiliations: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Lianju Shen,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Zhaowei Tu,

    Affiliations: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Weixiang Wang,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Bingyan Wang,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Hongmei Wang,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Yanling Wang,

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Johan H. van Es,

    Affiliation: Hubrecht Institute, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands

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  • Hans Clevers,

    Affiliation: Hubrecht Institute, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands

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  • Gustavo Leone,

    Affiliation: Departments of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, College of Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

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  • James C. Cross mail,

    hbwang@ioz.ac.cn (HBW); jcross@ucalgary.ca (JCC)

    Affiliation: Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada

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  • Haibin Wang mail

    hbwang@ioz.ac.cn (HBW); jcross@ucalgary.ca (JCC)

    Affiliation: State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China

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  • Published: April 16, 2013
  • DOI: 10.1371/journal.pbio.1001536

About the Authors

Jinhua Lu, Shuang Zhang, Shumin Wang, Shuangbo Kong, Qiang Wang, Lianju Shen, Zhaowei Tu, Weixiang Wang, Bingyan Wang, Hongmei Wang, Yanling Wang, Haibin Wang
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, People's Republic of China
Jinhua Lu, Shuang Zhang, Shuangbo Kong, Qiang Wang, Zhaowei Tu
Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China
Haruo Nakano, David G. Simmons, James C. Cross
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
Johan H. van Es, Hans Clevers
Hubrecht Institute, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
Gustavo Leone
Departments of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, College of Medicine, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JHL JCC HBW. Performed the experiments: JHL SZ HN DGS SMW SBK QW LJS ZWT BYW. Analyzed the data: JHL SZ HN DGS SMW QW LJS BYW HBW. Contributed reagents/materials/analysis tools: JHvE HC GL HMW YLW BYW WXW. Wrote the paper: JHL JCC HBW.