Advertisement
Research Article

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

  • Jing Xie equal contributor,

    equal contributor Contributed equally to this work with: Jing Xie, Li Tao

    Affiliations: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China

    X
  • Li Tao equal contributor,

    equal contributor Contributed equally to this work with: Jing Xie, Li Tao

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Clarissa J. Nobile,

    Affiliation: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Yaojun Tong,

    Affiliations: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China

    X
  • Guobo Guan,

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Yuan Sun,

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Chengjun Cao,

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Aaron D. Hernday,

    Affiliation: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Alexander D. Johnson,

    Affiliation: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

    X
  • Lixin Zhang,

    Affiliation: Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Feng-Yan Bai,

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Guanghua Huang mail

    huanggh@im.ac.cn

    Affiliation: State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

    X
  • Published: March 26, 2013
  • DOI: 10.1371/journal.pbio.1001525

About the Authors

Jing Xie, Li Tao, Yaojun Tong, Guobo Guan, Yuan Sun, Chengjun Cao, Feng-Yan Bai, Guanghua Huang
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Jing Xie, Yaojun Tong
University of Chinese Academy of Sciences, Beijing, China
Clarissa J. Nobile, Aaron D. Hernday, Alexander D. Johnson
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America
Lixin Zhang
Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

Corresponding Author

Email: huanggh@im.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JX LT CJN FB GH. Performed the experiments: JX LT CJN YT GG YS CC ADH GH. Analyzed the data: JX LT CJN YT GG YS CC ADH ADJ LZ FB GH. Contributed reagents/materials/analysis tools: JX LT CJN YT GG YS CC ADH ADJ LZ FB GH. Wrote the paper: JX LT CJN YT GG YS CC ADH ADJ LZ FB GH.