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Research Article

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory

  • William H. Light,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

    Current address: Salk Institute for Biological Studies, Molecular and Cell Biology Laboratory, La Jolla, California, United States of America

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  • Jonathan Freaney,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Varun Sood,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Abbey Thompson,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

    Current address: Department of Genetics, Stanford University School of Medicine, Stanford, California, United States of America

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  • Agustina D'Urso,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Curt M. Horvath,

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Jason H. Brickner mail

    j-brickner@northwestern.edu

    Affiliation: Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

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  • Published: March 26, 2013
  • DOI: 10.1371/journal.pbio.1001524

About the Authors

William H. Light, Jonathan Freaney, Varun Sood, Abbey Thompson, Agustina D'Urso, Curt M. Horvath, Jason H. Brickner
Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, United States of America

Corresponding Author

Email: j-brickner@northwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JHB WHL CMH. Performed the experiments: WHL AT JF VS AD. Analyzed the data: WHL JHB. Contributed reagents/materials/analysis tools: CMH JF. Wrote the paper: WHL JHB.