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Research Article

Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival

  • Daniel Thomas equal contributor,

    equal contributor Contributed equally to this work with: Daniel Thomas, Jason A. Powell

    Affiliation: Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

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  • Jason A. Powell equal contributor,

    equal contributor Contributed equally to this work with: Daniel Thomas, Jason A. Powell

    Affiliation: Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Benjamin D. Green,

    Affiliation: Australian Centre for Blood Diseases, Division of Blood Cancers, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia

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  • Emma F. Barry,

    Affiliation: Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Yuefang Ma,

    Affiliation: Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Joanna Woodcock,

    Affiliation: Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Stephen Fitter,

    Affiliation: School of Medical Sciences, Faculty of Health Science, University of Adelaide and Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

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  • Andrew C. W. Zannettino,

    Affiliation: School of Medical Sciences, Faculty of Health Science, University of Adelaide and Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Stuart M. Pitson,

    Affiliation: Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

    X
  • Timothy P. Hughes,

    Affiliation: School of Medical Sciences, Faculty of Health Science, University of Adelaide and Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

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  • Angel F. Lopez,

    Affiliation: Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia

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  • Peter R. Shepherd,

    Affiliation: Department of Molecular Medicine and Pathology and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, New Zealand

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  • Andrew H. Wei,

    Affiliations: Australian Centre for Blood Diseases, Division of Blood Cancers, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia, Department of Clinical Haematology, The Alfred Hospital, Melbourne, Victoria, Australia

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  • Paul G. Ekert,

    Affiliation: Walter and Eliza Hall Institute, Parkville, Victoria, Australia

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  • Mark A. Guthridge mail

    mark.guthridge@monash.edu

    Affiliations: Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia, Australian Centre for Blood Diseases, Division of Blood Cancers, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia

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  • Published: March 19, 2013
  • DOI: 10.1371/journal.pbio.1001515

About the Authors

Daniel Thomas, Jason A. Powell, Emma F. Barry, Mark A. Guthridge
Cell Growth and Differentiation Laboratory, Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
Benjamin D. Green, Andrew H. Wei, Mark A. Guthridge
Australian Centre for Blood Diseases, Division of Blood Cancers, Monash University, Alfred Medical Research and Education Precinct, Melbourne, Victoria, Australia
Yuefang Ma, Joanna Woodcock, Stuart M. Pitson, Angel F. Lopez
Division of Human Immunology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
Stephen Fitter, Andrew C. W. Zannettino, Timothy P. Hughes
School of Medical Sciences, Faculty of Health Science, University of Adelaide and Division of Haematology, Centre for Cancer Biology, SA Pathology, Adelaide, Australia
Peter R. Shepherd
Department of Molecular Medicine and Pathology and Maurice Wilkins Centre for Molecular Biodiscovery, University of Auckland, New Zealand
Andrew H. Wei
Department of Clinical Haematology, The Alfred Hospital, Melbourne, Victoria, Australia
Paul G. Ekert
Walter and Eliza Hall Institute, Parkville, Victoria, Australia

Corresponding Author

Email: mark.guthridge@monash.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DT PGE MAG. Performed the experiments: DT JAP BDG EFB YM JW SF MAG. Analyzed the data: DT JAP BDG EFB JW ACWZ SMP TPH AFL PRS AHW PGE MAG. Contributed reagents/materials/analysis tools: TPH AFL PRS AHW PGE. Wrote the paper: DT PGE MAG.