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Research Article

Neuronal Expression of Glucosylceramide Synthase in Central Nervous System Regulates Body Weight and Energy Homeostasis

  • Viola Nordström mail,

    v.nordstroem@dkfz-heidelberg.de

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Monja Willershäuser ,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany

    Member of German Center for Diabetes Research (DZD), Neuherberg, Germany.

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  • Silke Herzer,

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Jan Rozman ,

    Affiliations: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany, Molecular Nutritional Medicine, Else-Kröner Fresenius Center, Technische Universität München, Freising-Weihenstephan, Germany

    Member of German Center for Diabetes Research (DZD), Neuherberg, Germany.

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  • Oliver von Bohlen und Halbach,

    Affiliation: Institute for Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany

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  • Sascha Meldner,

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Ulrike Rothermel,

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Sylvia Kaden,

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Fabian C. Roth,

    Affiliation: Institute for Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany

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  • Clemens Waldeck,

    Affiliation: Institute for Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany

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  • Norbert Gretz,

    Affiliation: Medical Research Center, Heidelberg University, Heidelberg, Germany

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  • Martin Hrabě de Angelis ,

    Affiliation: German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany

    Member of German Center for Diabetes Research (DZD), Neuherberg, Germany.

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  • Andreas Draguhn,

    Affiliation: Institute for Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany

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  • Martin Klingenspor,

    Affiliation: Molecular Nutritional Medicine, Else-Kröner Fresenius Center, Technische Universität München, Freising-Weihenstephan, Germany

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  • Hermann-Josef Gröne equal contributor,

    equal contributor Contributed equally to this work with: Hermann-Josef Gröne, Richard Jennemann

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Richard Jennemann equal contributor

    equal contributor Contributed equally to this work with: Hermann-Josef Gröne, Richard Jennemann

    Affiliation: Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany

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  • Published: March 12, 2013
  • DOI: 10.1371/journal.pbio.1001506

About the Authors

Viola Nordström, Silke Herzer, Sascha Meldner, Ulrike Rothermel, Sylvia Kaden, Hermann-Josef Gröne, Richard Jennemann
Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
Monja Willershäuser, Jan Rozman, Martin Hrabě de Angelis
German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany
Jan Rozman, Martin Klingenspor
Molecular Nutritional Medicine, Else-Kröner Fresenius Center, Technische Universität München, Freising-Weihenstephan, Germany
Oliver von Bohlen und Halbach
Institute for Anatomy and Cell Biology, University of Greifswald, Greifswald, Germany
Fabian C. Roth, Clemens Waldeck, Andreas Draguhn
Institute for Physiology and Pathophysiology, Heidelberg University, Heidelberg, Germany
Norbert Gretz
Medical Research Center, Heidelberg University, Heidelberg, Germany

Corresponding Author

Email: v.nordstroem@dkfz-heidelberg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: VN HJG RJ MK JR AD MHA. Performed the experiments: VN MW SH SM UR SK FCR CW. Analyzed the data: VN MW JR FCR CW AD MK. Contributed reagents/materials/analysis tools: OBH NG. Wrote the paper: VN MW HJG JR MK.