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Research Article

Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains

  • Chen Wang equal contributor,

    equal contributor Contributed equally to this work with: Chen Wang, Jiayan Sang

    Affiliations: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China, Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America

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  • Jiayan Sang equal contributor,

    equal contributor Contributed equally to this work with: Chen Wang, Jiayan Sang

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Jiawei Wang,

    Affiliation: Department of Biology and Technology, Tsinghua University, Beijing, China

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  • Mingyan Su,

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Jennifer S. Downey,

    Affiliation: Division of Biomedical Science, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, United States of America

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  • Qinggan Wu,

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Shida Wang,

    Affiliation: Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

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  • Yongfei Cai,

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Xiaozheng Xu,

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Jun Wu,

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Dilani B. Senadheera,

    Affiliation: Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

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  • Dennis G. Cvitkovitch,

    Affiliation: Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

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  • Lin Chen,

    Affiliation: Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America

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  • Steven D. Goodman,

    Affiliation: Division of Biomedical Science, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, United States of America

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  • Aidong Han mail

    ahan@xmu.edu.cn

    Affiliation: State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China

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  • Published: February 26, 2013
  • DOI: 10.1371/journal.pbio.1001493

About the Authors

Chen Wang, Jiayan Sang, Mingyan Su, Qinggan Wu, Yongfei Cai, Xiaozheng Xu, Jun Wu, Aidong Han
State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
Chen Wang, Lin Chen
Department of Molecular and Computational Biology, University of Southern California, Los Angeles, California, United States of America
Jiawei Wang
Department of Biology and Technology, Tsinghua University, Beijing, China
Jennifer S. Downey, Steven D. Goodman
Division of Biomedical Science, Herman Ostrow School of Dentistry of University of Southern California, Los Angeles, California, United States of America
Shida Wang, Dilani B. Senadheera, Dennis G. Cvitkovitch
Dental Research Institute, Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada

Corresponding Author

Email: ahan@xmu.edu.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Initiated this project: AH LC SDG DBS DGC. Purified and crystallized proteins: CW. Performed mutagenesis and biochemical assays: JS MS QW XX SW JW. Solved and refined structure: JWW YC. Made initial expression constructs: JSD. Analyzed the data: AH. Contributed reagents/materials/analysis tools: AH LC SDG. Wrote the paper: AH.