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Research Article

The Molecular Mechanism of Substrate Engagement and Immunosuppressant Inhibition of Calcineurin

  • Simina Grigoriu,

    Affiliations: Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America, Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

    X
  • Rachel Bond,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

    X
  • Pilar Cossio,

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Jennifer A. Chen,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

    X
  • Nina Ly,

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

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  • Gerhard Hummer,

    Affiliation: Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

    X
  • Rebecca Page,

    Affiliation: Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America

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  • Martha S. Cyert mail,

    mcyert@stanford.edu (MSC) (MC); wolfgang_peti@brown.edu (WP) (WP)

    Affiliation: Department of Biology, Stanford University, Stanford, California, United States of America

    X
  • Wolfgang Peti mail

    mcyert@stanford.edu (MSC) (MC); wolfgang_peti@brown.edu (WP) (WP)

    Affiliations: Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America, Department of Chemistry, Brown University, Providence, Rhode Island, United States of America

    X
  • Published: February 26, 2013
  • DOI: 10.1371/journal.pbio.1001492

About the Authors

Simina Grigoriu, Wolfgang Peti
Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island, United States of America
Simina Grigoriu, Rebecca Page
Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, United States of America
Rachel Bond, Jennifer A. Chen, Nina Ly, Martha S. Cyert
Department of Biology, Stanford University, Stanford, California, United States of America
Pilar Cossio, Gerhard Hummer
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
Wolfgang Peti
Department of Chemistry, Brown University, Providence, Rhode Island, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SG RB PC GH RP MSC WP. Performed the experiments: SG RB NL JC PC RP WP. Analyzed the data: SG RB PC GH RP MSC WP. Wrote the paper: SG RB PC GH RP MSC WP.