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Research Article

A Force-Activated Trip Switch Triggers Rapid Dissociation of a Colicin from Its Immunity Protein

  • Oliver E. Farrance,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Eleanore Hann,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Renata Kaminska,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Nicholas G. Housden,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Sasha R. Derrington,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Colin Kleanthous,

    Affiliation: Department of Biochemistry, University of Oxford, Oxford, United Kingdom

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  • Sheena E. Radford,

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • David J. Brockwell mail

    d.j.brockwell@leeds.ac.uk

    Affiliations: School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom, Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom

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  • Published: February 19, 2013
  • DOI: 10.1371/journal.pbio.1001489

About the Authors

Oliver E. Farrance, Eleanore Hann, Sasha R. Derrington, Sheena E. Radford, David J. Brockwell
School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, United Kingdom
Oliver E. Farrance, Eleanore Hann, Sasha R. Derrington, Sheena E. Radford, David J. Brockwell
Astbury Centre for Structural Molecular Biology, University of Leeds, United Kingdom
Renata Kaminska, Nicholas G. Housden, Colin Kleanthous
Department of Biochemistry, University of Oxford, Oxford, United Kingdom

Corresponding Author

Email: d.j.brockwell@leeds.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: OF CK SR DB. Performed the experiments: OF EH RK NH SD. Analyzed the data: OF EH RK NH SD CK SR DB. Contributed reagents/materials/analysis tools: RK NH SD. Wrote the paper: OF SR DB.