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Research Article

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

  • Amandine Girousse,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Geneviève Tavernier,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Carine Valle,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Cedric Moro,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Niklas Mejhert,

    Affiliation: Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden

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  • Anne-Laure Dinel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Marianne Houssier,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Balbine Roussel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Aurèle Besse-Patin,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Marion Combes,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Lucile Mir,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Laurent Monbrun,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Véronic Bézaire,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Bénédicte Prunet-Marcassus,

    Affiliation: Physiogenex, Prologue Biotech, Labège-Innopole, France

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  • Aurélie Waget,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048,Team 2, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Isabelle Vila,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Sylvie Caspar-Bauguil,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France

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  • Katie Louche,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Marie-Adeline Marques,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Aline Mairal,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Marie-Laure Renoud,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Jean Galitzky,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Cecilia Holm,

    Affiliation: Department of Experimental Medical Science, Lund University, Lund, Sweden

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  • Etienne Mouisel,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Claire Thalamas,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, INSERM, Clinical Investigation Center, Toulouse, France

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  • Nathalie Viguerie,

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France

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  • Thierry Sulpice,

    Affiliation: Physiogenex, Prologue Biotech, Labège-Innopole, France

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  • Rémy Burcelin,

    Affiliations: University of Toulouse, UMR1048, Paul Sabatier University, France, INSERM, UMR1048,Team 2, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France

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  • Peter Arner,

    Affiliation: Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden

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  • Dominique Langin mail

    dominique.langin@inserm.fr

    Affiliations: INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France, University of Toulouse, UMR1048, Paul Sabatier University, France, Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France

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  • Published: February 19, 2013
  • DOI: 10.1371/journal.pbio.1001485

About the Authors

Amandine Girousse, Geneviève Tavernier, Carine Valle, Cedric Moro, Anne-Laure Dinel, Marianne Houssier, Balbine Roussel, Aurèle Besse-Patin, Marion Combes, Lucile Mir, Laurent Monbrun, Véronic Bézaire, Isabelle Vila, Sylvie Caspar-Bauguil, Katie Louche, Marie-Adeline Marques, Aline Mairal, Etienne Mouisel, Claire Thalamas, Nathalie Viguerie, Dominique Langin
INSERM, UMR1048, Obesity Research Laboratory, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
Amandine Girousse, Geneviève Tavernier, Carine Valle, Cedric Moro, Anne-Laure Dinel, Marianne Houssier, Balbine Roussel, Aurèle Besse-Patin, Marion Combes, Lucile Mir, Laurent Monbrun, Véronic Bézaire, Aurélie Waget, Isabelle Vila, Sylvie Caspar-Bauguil, Katie Louche, Marie-Adeline Marques, Aline Mairal, Marie-Laure Renoud, Jean Galitzky, Etienne Mouisel, Claire Thalamas, Nathalie Viguerie, Rémy Burcelin, Dominique Langin
University of Toulouse, UMR1048, Paul Sabatier University, France
Niklas Mejhert, Peter Arner
Department of Medicine, Karolinska Institute at Karolinska Hospital, Huddinge, Stockholm, Sweden
Bénédicte Prunet-Marcassus, Thierry Sulpice
Physiogenex, Prologue Biotech, Labège-Innopole, France
Aurélie Waget, Rémy Burcelin
INSERM, UMR1048,Team 2, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
Sylvie Caspar-Bauguil, Dominique Langin
Toulouse University Hospitals, Laboratory of Clinical Biochemistry, Toulouse, France
Marie-Laure Renoud, Jean Galitzky
INSERM, UMR1048, Team 1, I2MC, Institute of Metabolic and Cardiovascular Diseases, Toulouse, France
Cecilia Holm
Department of Experimental Medical Science, Lund University, Lund, Sweden
Claire Thalamas
Toulouse University Hospitals, INSERM, Clinical Investigation Center, Toulouse, France

Corresponding Author

Email: dominique.langin@inserm.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AG GT CT NV TS RB PA DL. Performed the experiments: AG GT CV CM NM ALD MH ABP MC LMir LMonbrun VB BPM AW IV KL MAM AM MLR JG. Analyzed the data: AG GT CV CM NM BR BPM SCB TS CH EM RB PA DL. Contributed reagents/materials/analysis tools: CH. Wrote the paper: AG DL.