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Research Article

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome

  • Cong Cao,

    Affiliations: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America, Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China

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  • Mengia S. Rioult-Pedotti,

    Affiliation: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America

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  • Paolo Migani,

    Affiliation: Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, Italy

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  • Crystal J. Yu,

    Affiliation: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America

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  • Rakesh Tiwari,

    Affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States of America

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  • Keykavous Parang,

    Affiliation: Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States of America

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  • Mark R. Spaller,

    Affiliation: Norris Cotton Cancer Center and Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America

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  • Dennis J. Goebel mail,

    Dgoebel@med.wayne.edu (DJG); John_Marshall@Brown.edu (JM)

    Affiliation: Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan, United States of America

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  • John Marshall mail

    Dgoebel@med.wayne.edu (DJG); John_Marshall@Brown.edu (JM)

    Affiliation: Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America

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  • Published: February 12, 2013
  • DOI: 10.1371/journal.pbio.1001478

About the Authors

Cong Cao, Mengia S. Rioult-Pedotti, Crystal J. Yu, John Marshall
Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island, United States of America
Cong Cao
Institute of Neuroscience, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou, China
Paolo Migani
Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, Italy
Rakesh Tiwari, Keykavous Parang
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island, United States of America
Mark R. Spaller
Norris Cotton Cancer Center and Department of Pharmacology and Toxicology, Dartmouth Medical School, Lebanon, New Hampshire, United States of America
Dennis J. Goebel
Department of Anatomy and Cell Biology, Wayne State University, Detroit, Michigan, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JM CC DJG PM. Performed the experiments: CC MSRP PM CJY RT DJG JM. Analyzed the data: CC MSRP PM DJG JM. Contributed reagents/materials/analysis tools: MRS RT KP. Wrote the paper: JM DJG CC MSRP PM.