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Research Article

Localized DNA Demethylation at Recombination Intermediates during Immunoglobulin Heavy Chain Gene Assembly

  • Roza Selimyan,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Rachel M. Gerstein,

    Affiliation: Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Irina Ivanova,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Patricia Precht,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Ramesh Subrahmanyam,

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Thomas Perlot,

    Affiliation: The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

    Current address: Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria

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  • Frederick W. Alt,

    Affiliation: The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Ranjan Sen mail

    senranja@grc.nia.nih.gov

    Affiliation: Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America

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  • Published: January 29, 2013
  • DOI: 10.1371/journal.pbio.1001475

About the Authors

Roza Selimyan, Irina Ivanova, Patricia Precht, Ramesh Subrahmanyam, Ranjan Sen
Laboratory of Molecular Biology and Immunology, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, United States of America
Rachel M. Gerstein
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
Thomas Perlot, Frederick W. Alt
The Howard Hughes Medical Institute, The Children's Hospital, Immune Disease Institute and Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

Corresponding Author

Email: senranja@grc.nia.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RSelimyan, RSen. Performed the experiments: RSelimyan, II, PP. Analyzed the data: RSelimyan, RSen. Contributed reagents/materials/analysis tools: RMG, RSubrahmanyam, TP, FWA. Wrote the paper: RSelimyan, RSen.