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Research Article

ELF5 Suppresses Estrogen Sensitivity and Underpins the Acquisition of Antiestrogen Resistance in Luminal Breast Cancer

  • Maria Kalyuga ,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    DGO and MK contributed equally to this work and are joint first authors.

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  • David Gallego-Ortega ,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    DGO and MK contributed equally to this work and are joint first authors.

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  • Heather J. Lee,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Daniel L. Roden,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Mark J. Cowley,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • C. Elizabeth Caldon,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Andrew Stone,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Stephanie L. Allerdice,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Fatima Valdes-Mora,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Rosalind Launchbury,

    Affiliation: Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

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  • Aaron L. Statham,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Nicola Armstrong,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, School of Mathematics and Statistics, and Prince of Wales Clinical School, University of New South Wales Kensington NSW, Australia

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  • M. Chehani Alles,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Adelaide Young,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, University of Bath, Bath, United Kingdom

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  • Andrea Egger,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Wendy Au,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Catherine L. Piggin,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Cara J. Evans,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Anita Ledger,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Tilman Brummer,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

    Current address: Institute for Molecular Medicine and Cell Research, Freiburg, Germany

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  • Samantha R. Oakes,

    Affiliation: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia

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  • Warren Kaplan,

    Affiliations: Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Julia M. W. Gee,

    Affiliation: Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

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  • Robert I. Nicholson,

    Affiliation: Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom

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  • Robert L. Sutherland †,

    † Deceased.

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Alexander Swarbrick,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Matthew J. Naylor,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia, Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia

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  • Susan J. Clark,

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Jason S. Carroll,

    Affiliation: Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom

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  • Christopher J. Ormandy mail

    c.ormandy@garvan.org.au

    Affiliations: Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia, St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pbio.1001461

About the Authors

Maria Kalyuga, David Gallego-Ortega, Heather J. Lee, Daniel L. Roden, Mark J. Cowley, C. Elizabeth Caldon, Andrew Stone, Stephanie L. Allerdice, Fatima Valdes-Mora, Aaron L. Statham, Nicola Armstrong, M. Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L. Piggin, Cara J. Evans, Anita Ledger, Tilman Brummer, Samantha R. Oakes, Robert L. Sutherland, Alexander Swarbrick, Matthew J. Naylor, Susan J. Clark, Christopher J. Ormandy
Cancer Research Program and The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Mark J. Cowley, Warren Kaplan
Peter Wills Bioinformatics Centre, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia
Rosalind Launchbury, Jason S. Carroll
Cancer Research UK, Cambridge Research Institute, Cambridge, United Kingdom
Nicola Armstrong
School of Mathematics and Statistics, and Prince of Wales Clinical School, University of New South Wales Kensington NSW, Australia
Adelaide Young
University of Bath, Bath, United Kingdom
Warren Kaplan, Robert L. Sutherland, Alexander Swarbrick, Matthew J. Naylor, Susan J. Clark, Christopher J. Ormandy
St Vincent's Clinical School, St Vincent's Hospital and University of New South Wales, Darlinghurst NSW, Australia
Julia M. W. Gee, Robert I. Nicholson
Breast Cancer (Molecular Pharmacology) Group, Cardiff School of Pharmacy and Pharmaceutical Science, Cardiff University, Cardiff, Wales, United Kingdom
Matthew J. Naylor
Discipline of Physiology & Bosch Institute, School of Medical Sciences, University of Sydney, NSW, Australia

Corresponding Author

Email: c.ormandy@garvan.org.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MK DGO HJL SRO CEC CA TB ASw MJN, JSC CJO. Performed the experiments: MK DGO HL CEC SLA FVM RL ASto CA AY AE WA CP CE AL. Analyzed the data: MK DGO HL MC CEC ASto SLA FVM RL ASw NA CA DR AY AE WA CP CE AL WK JMWG ASta MJNSC JSC CJO. Contributed reagents/materials/analysis tools: RIN RLS. Wrote the paper: All authors.