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Research Article

Order–Disorder Transitions Govern Kinetic Cooperativity and Allostery of Monomeric Human Glucokinase

  • Mioara Larion equal contributor,

    equal contributor Contributed equally to this work with: Mioara Larion, Roberto Kopke Salinas

    Affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America

    X
  • Roberto Kopke Salinas equal contributor,

    equal contributor Contributed equally to this work with: Mioara Larion, Roberto Kopke Salinas

    Affiliations: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America, Institute of Chemistry, University of São Paulo, São Paulo, Brazil, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, United States of America

    X
  • Lei Bruschweiler-Li,

    Affiliations: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, United States of America

    X
  • Brian G. Miller mail,

    miller@chem.fsu.edu (BGM); bruschweiler@magnet.fsu.edu (RB)

    Affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America

    X
  • Rafael Brüschweiler mail

    miller@chem.fsu.edu (BGM); bruschweiler@magnet.fsu.edu (RB)

    Affiliations: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America, National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, United States of America

    X
  • Published: December 18, 2012
  • DOI: 10.1371/journal.pbio.1001452

About the Authors

Mioara Larion, Roberto Kopke Salinas, Lei Bruschweiler-Li, Brian G. Miller, Rafael Brüschweiler
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, United States of America
Roberto Kopke Salinas
Institute of Chemistry, University of São Paulo, São Paulo, Brazil
Roberto Kopke Salinas, Lei Bruschweiler-Li, Rafael Brüschweiler
National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ML RKS LB BGM RB. Performed the experiments: ML RKS. Analyzed the data: ML RKS LB BGM RB. Contributed reagents/materials/analysis tools: BGM RB. Wrote the paper: ML RKS LB BGM RB.