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Research Article

The Mechanism of Toxicity in HET-S/HET-s Prion Incompatibility

  • Carolin Seuring,

    Affiliation: Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • Jason Greenwald,

    Affiliation: Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • Christian Wasmer,

    Affiliation: Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

    Current address: Harvard Medical School, Boston, Massachusetts, United States of America

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  • Roger Wepf,

    Affiliation: Electron Microscopy ETH Zurich (EMEZ), Zürich, Switzerland

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  • Sven J. Saupe,

    Affiliation: Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et Génétique Cellulaires, UMR-5095 CNRS/Université de Bordeaux 2, Bordeaux, France

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  • Beat H. Meier,

    Affiliation: Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • Roland Riek mail

    roland.riek@phys.chem.ethz.ch

    Affiliation: Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland

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  • Published: December 27, 2012
  • DOI: 10.1371/journal.pbio.1001451

About the Authors

Carolin Seuring, Jason Greenwald, Christian Wasmer, Beat H. Meier, Roland Riek
Laboratory of Physical Chemistry, ETH Zürich, Zürich, Switzerland
Roger Wepf
Electron Microscopy ETH Zurich (EMEZ), Zürich, Switzerland
Sven J. Saupe
Laboratoire de Génétique Moléculaire des Champignons, Institut de Biochimie et Génétique Cellulaires, UMR-5095 CNRS/Université de Bordeaux 2, Bordeaux, France

Corresponding Author

Email: roland.riek@phys.chem.ethz.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CS JG CW RW SS BM RR. Performed the experiments: CS JG CW RW. Analyzed the data: CS JG CW RW BM RR. Contributed reagents/materials/analysis tools: CS JG CW RW SS BM RR. Wrote the paper: CS JG CW RW SS BM RR.