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Research Article

Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides

  • Nuria Izquierdo-Useros mail,

    nizquierdo@irsicaixa.es (NI-U); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

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  • Maier Lorizate equal contributor,

    equal contributor Contributed equally to this work with: Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

    Current address: Unidad de Biofisica (CSIC-UPV/EHU) and Departamento de Bioquímica, Universidad del Pais Vasco, Bilbao, Spain

    X
  • Maria C. Puertas equal contributor,

    equal contributor Contributed equally to this work with: Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

    X
  • Maria T. Rodriguez-Plata equal contributor,

    equal contributor Contributed equally to this work with: Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

    X
  • Nadine Zangger equal contributor,

    equal contributor Contributed equally to this work with: Maier Lorizate, Maria C. Puertas, Maria T. Rodriguez-Plata, Nadine Zangger

    Affiliation: Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland

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  • Elina Erikson,

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

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  • Maria Pino,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

    X
  • Itziar Erkizia,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

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  • Bärbel Glass,

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

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  • Bonaventura Clotet,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

    X
  • Oliver T. Keppler,

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

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  • Amalio Telenti,

    Affiliation: Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland

    X
  • Hans-Georg Kräusslich mail,

    nizquierdo@irsicaixa.es (NI-U); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

    H-GK and JM-P are joint senior authors on this work.

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  • Javier Martinez-Picado mail

    nizquierdo@irsicaixa.es (NI-U); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliations: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    H-GK and JM-P are joint senior authors on this work.

    X
  • Published: December 18, 2012
  • DOI: 10.1371/journal.pbio.1001448

About the Authors

Nuria Izquierdo-Useros, Maria C. Puertas, Maria T. Rodriguez-Plata, Maria Pino, Itziar Erkizia, Bonaventura Clotet, Javier Martinez-Picado
AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
Maier Lorizate, Elina Erikson, Bärbel Glass, Oliver T. Keppler, Hans-Georg Kräusslich
Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany
Nadine Zangger, Amalio Telenti
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
Javier Martinez-Picado
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Corresponding Authors

Competing Interests

I have read the journal's policy and have the following conflicts: A patent application based on this work has been filed (EP11382392.6, 2011). The authors declare that no other competing financial interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: NI-U ML JM-P H-GK. Performed the experiments: NI-U ML MCP MTR-P NZ EE MP BG IE. Analyzed the data: NI-U ML MCP MTR-P NZ EE MP BG IE OK AT. Contributed reagents/materials/analysis tools: BC. Wrote the paper: NI-U JM-P H-GK.