Advertisement
Research Article

Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication

  • Karin Voordeckers equal contributor,

    equal contributor Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

    X
  • Chris A. Brown equal contributor,

    equal contributor Contributed equally to this work with: Karin Voordeckers, Chris A. Brown

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium, Fathom Information Design, Boston, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America

    X
  • Kevin Vanneste,

    Affiliations: VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

    X
  • Elisa van der Zande,

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

    X
  • Arnout Voet,

    Affiliation: Laboratory for Molecular en Structural Biology, KU Leuven, Leuven, Belgium

    X
  • Steven Maere mail,

    Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

    Affiliations: VIB Department of Plant Systems Biology, Gent, Belgium, Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium

    X
  • Kevin J. Verstrepen mail

    Steven.Maere@psb.vib-ugent.be (SM); Kevin.Verstrepen@biw.vib-kuleuven.be (KJV)

    Affiliations: VIB Laboratory for Systems Biology, Leuven, Belgium, CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium

    X
  • Published: December 11, 2012
  • DOI: 10.1371/journal.pbio.1001446

About the Authors

Karin Voordeckers, Chris A. Brown, Elisa van der Zande, Kevin J. Verstrepen
VIB Laboratory for Systems Biology, Leuven, Belgium
Karin Voordeckers, Chris A. Brown, Elisa van der Zande, Kevin J. Verstrepen
CMPG Laboratory for Genetics and Genomics, KU Leuven, Leuven, Belgium
Chris A. Brown
Fathom Information Design, Boston, Massachusetts, United States of America
Chris A. Brown
Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, Massachusetts, United States of America
Chris A. Brown
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts, United States of America
Kevin Vanneste, Steven Maere
VIB Department of Plant Systems Biology, Gent, Belgium
Kevin Vanneste, Steven Maere
Department of Plant Biotechnology and Bioinformatics, Ghent University, Gent, Belgium
Arnout Voet
Laboratory for Molecular en Structural Biology, KU Leuven, Leuven, Belgium

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: C. Brown, S. Maere, K. Verstrepen. Performed the experiments: K. Voordeckers, C. Brown, E. van der Zande. Analyzed the data: K. Voordeckers, C. Brown, K. Vanneste, A. Voet, S. Maere, K. Verstrepen. Wrote the paper: K. Voordeckers, C. Brown, K. Vanneste, A. Voet, S. Maere, K. Verstrepen. Carried out molecular evolution analyses: C. Brown, K. Vanneste, S. Maere. Carried out structural analyses: A. Voet.