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Research Article

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

  • Xin Xiong,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Yan Hao,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Kan Sun,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Jiaxing Li,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Xia Li,

    Affiliation: Neuroscience Center for Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America

    X
  • Bibhudatta Mishra,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Pushpanjali Soppina,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Chunlai Wu,

    Affiliation: Neuroscience Center for Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America

    X
  • Richard I. Hume,

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Catherine A. Collins mail

    collinca@umich.edu

    Affiliation: Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Published: December 04, 2012
  • DOI: 10.1371/journal.pbio.1001440

About the Authors

Xin Xiong, Yan Hao, Kan Sun, Jiaxing Li, Bibhudatta Mishra, Pushpanjali Soppina, Richard I. Hume, Catherine A. Collins
Department of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, United States of America
Xia Li, Chunlai Wu
Neuroscience Center for Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America

Corresponding Author

Email: collinca@umich.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: XX YH CW CAC. Performed the experiments: XX YH KS JL XL BM PS CW. Analyzed the data: XX YH KS JL BM CW RIH CAC. Wrote the paper: XX CAC. Contributed assistance with electrophysiology recordings: RIH.