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Research Article

Bax Activation Initiates the Assembly of a Multimeric Catalyst that Facilitates Bax Pore Formation in Mitochondrial Outer Membranes

  • Yulia Kushnareva,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Alexander Y. Andreyev,

    Affiliation: Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

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  • Tomomi Kuwana,

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Donald D. Newmeyer mail

    don@liai.org

    Affiliation: La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America

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  • Published: September 25, 2012
  • DOI: 10.1371/journal.pbio.1001394

About the Authors

Yulia Kushnareva, Tomomi Kuwana, Donald D. Newmeyer
La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
Alexander Y. Andreyev
Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: don@liai.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: YK TK AYA DDN. Performed the experiments: YK TK AYA. Analyzed the data: YK TK AYA DDN. Wrote the paper: YK AYA DDN.