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Research Article

Multi-Scale In Vivo Systems Analysis Reveals the Influence of Immune Cells on TNF-α-Induced Apoptosis in the Intestinal Epithelium

  • Ken S. Lau,

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Virna Cortez-Retamozo,

    Affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Sarah R. Philips,

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Mikael J. Pittet,

    Affiliation: Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Douglas A. Lauffenburger,

    Affiliations: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kevin M. Haigis mail

    khaigis@partners.org

    Affiliations: Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America, Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Published: September 25, 2012
  • DOI: 10.1371/journal.pbio.1001393

About the Authors

Ken S. Lau, Sarah R. Philips, Kevin M. Haigis
Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
Ken S. Lau, Sarah R. Philips, Kevin M. Haigis
Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
Ken S. Lau, Virna Cortez-Retamozo, Sarah R. Philips, Mikael J. Pittet, Kevin M. Haigis
Center for Systems Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
Ken S. Lau, Kevin M. Haigis
Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
Ken S. Lau, Douglas A. Lauffenburger
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Ken S. Lau, Douglas A. Lauffenburger
Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

Corresponding Author

Email: khaigis@partners.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KSL MJP DAL KMH. Performed the experiments: KSL VCR SRP. Analyzed the data: KSL VCR MJP DAL KMH. Wrote the paper: KSL DAL KMH.